Conserved Protein Domain Family
RING-HC_HLTF

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cd16509: RING-HC_HLTF 
RING finger, HC subclass, found in helicase-like transcription factor (HLTF) and similar proteins
HLTF, also known as DNA-binding protein/plasminogen activator inhibitor 1 regulator, or HIP116, or RING finger protein 80, or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3, or sucrose nonfermenting protein 2-like 3, is a yeast RAD5 homolog found in mammals. It has both E3 ubiquitin ligase and DNA helicase activities, and plays a pivotal role in the template-switching pathway of DNA damage tolerance. It is involved in Lys-63-linked poly-ubiquitination of proliferating cell nuclear antigen (PCNA) at Lys-164 and in the regulation of DNA damage tolerance. It shows double-stranded DNA translocase activity with 3'-5' polarity, thereby facilitating regression of the replication fork. HLTF contains an N-terminal HIRAN (HIP116 and RAD5 N-terminal) domain, a SWI/SNF helicase domain that is divided into N- and C-terminal parts by an insertion of a C3HC4-type RING-HC finger involved in the poly-ubiquitination of PCNA.
Statistics
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PSSM-Id: 319423
View PSSM: cd16509
Aligned: 18 rows
Threshold Bit Score: 70.7892
Threshold Setting Gi: 749726365
Created: 7-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens BRCA1 (1JM7) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
Feature 1           #  #           # #  #  #                #  # 
gi 60390864   758 EECAICLDSLtvPVITHCAHVFCKPCICQVIqneq---phaKCPLCR 801
gi 780150221 1480 EECCICLESVqdPVVTRCAHVFCQRCIEEVIisek---eraCCPLCR 1523
gi 919011296  224 EECSICLDPLntPVITRCVHVFCKPCIERVIqteg---egaNCPLCR 267
gi 759250716  721 EDCCVCLDSLnnPVITACAHTFCRACIERVIdt------qhKCPMCR 761
gi 303279062  600 DDCCICLNTMhaPVVTRCAHVFCRGCLAPALer------kaTCPLCR 640
gi 163776505  880 PECSVCLDTIdePVVTPCAHYGCRVCMENAVdn------fhECPLCR 920
gi 470302447 1041 KECPICLDFPedIVVTPCLHTGCKGCMQHTVar------lhSCPVCR 1081
gi 999987154  372 EECAVCLESLtdPVITPCAHVFCSACIRDVLqseg---lapTCPMCR 415
gi 857972852  788 TTCAICLAVAdqPVITVCFHLFCRNCIVNILdrk----gngKCPSCR 830
gi 749726365   23 IICPICLDTPkpPVITPCCHIFCWKCIVQDAlvrrdlqkppKCPLCQ 69

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