Conserved Protein Domain Family
RING1-HC_LONFs

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cd16513: RING1-HC_LONFs 
RING finger 1, HC subclass, found in the LON peptidase N-terminal domain and RING finger proteins family
The LON peptidase N-terminal domain and RING finger proteins family includes LONRF1 (also known as RING finger protein 191 or RNF191), LONRF2 (also known as RING finger protein 192 or RNF192, or neuroblastoma apoptosis-related protease), LONRF3 (also known as RING finger protein 127 or RNF127), which are characterized by containing two C3HC4-type RING-HC fingers, four tetratricopeptide (TPR) repeats, and one N-terminal domain of the ATP-dependent protease La (LON) domain at the C-terminus. Their biological function remain unclear. This family corresponds to the first RING-HC finger.
Statistics
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PSSM-Id: 319427
View PSSM: cd16513
Aligned: 15 rows
Threshold Bit Score: 33.1925
Threshold Setting Gi: 257051033
Created: 31-Jul-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens TRAF2 (3KNV) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
Feature 1        #  #                   # #  #  #                       #    # 
gi 257051033 123 CLGCRGFLse--------pvTVPCGHSYCRRCLRrel---------------rarCRl--CR 159
gi 556991265 118 CRGCRGFLae--------pvTAPCGHSYCRRCLWkgl---------------lsrCKv--CR 154
gi 301610356  62 CPGCGGFLre--------pvSTQCGHTYCRCCLRgep---------------rsrCRl--CR 98
gi 469832261 108 CPGCHCFIae--------pvTVTCGHTYCRRCLQhst---------------fsqCKv--CN 144
gi 313104224 143 CPRCRRLLhk--------pvTLPCGLTVCKRCVEpgparpqvrrvnvvlsgllekCFpaeCR 196
gi 3915443   189 CPRCQEPLgtskskeksalwATKCGHVYCGSCAKvlktsk----------rsqskCLvndCG 240
gi 685396223  16 CPSCNALRylnpd--mvlktNEKCYHQICDTCVRhnyen------------gqarCLikgCE 63
gi 116779205 213 CPSCKDTLtnrh----tlmaISTCGHIYCKKCAEkfvk-------------ldgvCFv--CN 255
gi 168049908 215 CPSCSVTLtdtl----tlvaVSTCGHVFCKKCADkfva-------------pdkiCLa--CN 257
gi 18407260  221 CPSCKVTLtntm----slvaLSSCGHVFCKKCAEkfmp-------------vdkvCLv--CD 263

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