Conserved Protein Domain Family
RING2-HC_LONFs

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cd16514: RING2-HC_LONFs 
RING finger 2, HC subclass, found in the LON peptidase N-terminal domain and RING finger proteins family
The LON peptidase N-terminal domain and RING finger proteins family includes LONRF1 (also known as RING finger protein 191 or RNF191), LONRF2 (also known as RING finger protein 192 or RNF192, or neuroblastoma apoptosis-related protease), LONRF3 (also known as RING finger protein 127 or RNF127), which are characterized by containing two C3HC4-type RING-HC fingers, four tetratricopeptide (TPR) repeats, and one N-terminal domain of the ATP-dependent protease La (LON) domain at the C-terminus. Their biological function remain unclear. This family corresponds to the second RING-HC finger.
Statistics
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PSSM-Id: 319428
View PSSM: cd16514
Aligned: 24 rows
Threshold Bit Score: 85.0695
Threshold Setting Gi: 226460931
Created: 3-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus Hakai (3VK6) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
Feature 1           #  #           # #  #  #          #  # 
gi 257051033 476 DFECSLCMRLFFePVTTPCGHSFCKNCLERCLDHapyCPLCK 517
gi 699243186 452 DLECSLCMRLLCdPVCTPCGHMFCQGCIERCLDHksqCPLCK 493
gi 443716928   8 DFECTLCYRILFlPVTTPCGHVFCRHCLDRCLDHttvCPLCK 49
gi 585661678 355 DFECSLCFRLLYaPVTTPCGHMFCCHCLDRCLDHsnrCPLCK 396
gi 675384646 111 DFECPLCMRILWePVTTPCGHSFCRFCLNRCLDHqptCPLCK 152
gi 760442433 208 DLECPLCLKLLYrPVTTPCGHSFCQACLPRCLDHtsrCPTCR 249
gi 919081566 437 DFECSLCFRLLYePVTTPCGHVFCRGCLDRCLDHnnsCPLCK 478
gi 294954204  27 TFECPICLRLLVePVTTACGHTFCKNCITKTMDHrqlCPSCR 68
gi 313224371 176 DLECPLCLRVYWnPDVTPCGHTFCSDCLERTLDHdpkCPLCK 217
gi 924122458 334 ELTCEICFMLLCnPITTPCQHTFCSTCLERSLDHstkCPLCR 375

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