Conserved Protein Domain Family
RING-HC_LONFs_rpt2
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cd16514: RING-HC_LONFs_rpt2 
second RING finger, HC subclass, found in the LON peptidase N-terminal domain and RING finger protein family
The LON peptidase N-terminal domain and RING finger protein family includes LONRF1 (also known as RING finger protein 191 or RNF191), LONRF2 (also known as RING finger protein 192, RNF192, or neuroblastoma apoptosis-related protease), LONRF3 (also known as RING finger protein 127 or RNF127), which are characterized by containing two C3HC4-type RING-HC fingers, four tetratricopeptide (TPR) repeats, and an ATP-dependent protease La (LON) substrate-binding domain at the C-terminus. Their biological functions remain unclear. This model corresponds to the second RING-HC finger.
Links
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Statistics
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PSSM-Id: 438177
Aligned: 28 rows
Threshold Bit Score: 66.9065
Created: 3-May-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #  #           # #  #  #                      #  #    
Q17RB8        476 DFECSLCMRLFFEPVTTPCGHSFCKNCLERCLDHa------------pYCPLCKESL 520  human
XP_011398285  208 DLECPLCLKLLYRPVTTPCGHSFCQACLPRCLDHt------------sRCPTCRTPM 252  Auxenochlorella protothecoides
EEH58225       87 TCECVLCLELFCDPVTTPCGHTFCRRCLARALDHsd----------dpRCPTCRSVV 133  Micromonas pusilla CCMP1545
XP_004337456  126 DFECVLCLKVFYDPVTTPCGHTFCRSCLFRAMDHg------------tQCPLCRGVV 170  Acanthamoeba castellanii str. Neff
XP_024524849  182 DFDCTLCLKLLYNPVTTPCGHSFCRACLLQALDHg------------nKCPMCRTVL 226  Selaginella moellendorffii
XP_024395894  186 DLDCTLCLKLLHQPITTPCGHSFCRACLLQALDHg------------nKCPMCRTVI 230  Physcomitrium patens
NP_849688     193 DFDCTVCLKLLYEPATTPCGHTFCRSCLFQSMDRg------------nKCPLCRTVI 237  thale cress
XP_012553535  337 DLNCVLCFRLLYKPTSTPCGHTFCSACLERSLDHn------------yYCAVCRSSI 381  swiftwater hydra
NP_001246660  685 DFDCVVCSRTLWKPVVTPCGHTYCLVCLDRCMDYn------------sPCPLCMSPL 729  fruit fly
TPX70137       54 SHNCPLCLKLLYKPIRTSCSHTFCQACLSRYFATmftprtqqdgtvhkPCPMCRQLL 110  Spizellomyces sp. 'palustris'

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