Conserved Protein Domain Family
RING-HC_LRSAM1

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cd16515: RING-HC_LRSAM1 
RING finger, HC subclass, found in leucine-rich repeat and sterile alpha motif-containing protein 1 (LRSAM1) and similar proteins
LRSAM1, also known as Tsg101-associated ligase (TAL), or RIFLE, is an E3 ubiquitin-protein ligase that physically associates with, and selectively ubiquitylates, Tsg101, an E2-like molecule that regulates vesicular trafficking processes in yeast and mammals. It regulates a Tsg101-associated complex responsible for the sorting of cargo into cytoplasm-containing vesicles that bud at the multivesicular body and at the plasma membrane. LRSAM1 is a multidomain protein containing an N-terminal leucine-rich repeat (LRR), followed by several recognizable motifs, including an ezrin-radixin-moezin (ERM) domain, a coiled-coil (CC) region, a SAM domain, and a C-terminal C3HC4-type RING-HC finger domain.
Statistics
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PSSM-Id: 319429
View PSSM: cd16515
Aligned: 17 rows
Threshold Bit Score: 63.4589
Threshold Setting Gi: 18129286
Created: 6-Nov-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens MYLIP (2YHO; also known as IDOL) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
Feature 1         #  #           # #   #  #      #  #    
gi 62511890  674 ECVVCLEreaQMIFLNCGHVCCCQQCCQPLrtCPLCRQDI 713
gi 675388084 645 ECVICLDvesSAVFLPCGHVCCCLKCSGGIelCPMCRTAI 684
gi 585668740 826 ECVVCMDkmsDMVFLPCGHVCCCYQCSSTIseCPMCRGRI 865
gi 118344212 673 ECVVCLDrnsDTIFLPCGHVCACFICSTQLqsCPMCRSDV 712
gi 30696917  295 LCVICLEqeyNAVFVPCGHMCCCTACSSHLtsCPLCRRRI 334
gi 168002970 304 LCVICLEqdyNAVFLPCGHMCCCTSCSAQLtsCPLCRRHI 343
gi 18129286   32 LCIICLEqeyNVVFVPCGHMCCCTSCSSRLseCPLCRGDI 71
gi 405952849 419 ECVICLDrqsAVIFLSCGHVCCCNECSIPLkeCPLCRGAI 458
gi 302772771 298 LCVICLEqeyNAVFVPCGHMCCCISCSAQLqnCPLCRRRI 337
gi 674594532 649 ECCICQDaqcSIIFLPCGHVCCCEICSAKVyqCPLCRVVV 688

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