1G25


Conserved Protein Domain Family
RING-HC_MAT1

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cd16517: RING-HC_MAT1 
Click on image for an interactive view with Cn3D
RING finger, HC subclass, found in RING finger protein MAT1
MAT1, also known as CDK-activating kinase assembly factor MAT1, CDK7/cyclin-H assembly factor, cyclin-G1-interacting protein, menage a trois, RING finger protein 66 (RNF66), p35, or p36, is involved in cell cycle control and in RNA transcription by RNA polymerase II. It associates primarily with the catalytic subunit cyclin-dependent kinase 7 (CDK7) and the regulatory subunit cyclin H to form the CDK-activating kinase (CAK) complex that can further associate with the core-TFIIH to form the transcription factor IIH (TFIIH) basal transcription/DNA repair factor, which activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. MAT1 contains an N-terminal C3HC4-type RING-HC finger, a central coiled coil domain, and a C-terminal domain rich in hydrophobic residues.
Statistics
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PSSM-Id: 319431
View PSSM: cd16517
Aligned: 22 rows
Threshold Bit Score: 87.4292
Threshold Setting Gi: 514698126
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteRING-HC finger
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:1G25; Homo sapiens TFIIH MAT1 subunit binds two Zn2+ ions through its RING-HC finger.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
Feature 1        #  #                # #  #  #           #  #     
1G25_A         6 CPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRgagnCPECGTPLR 54
gi 405954857   6 CPRCKTTKYRNPSLKLLVNVCGHSLCETCVEALFVKgsgiCPECGTALR 54
gi 291230504   6 CPHCKTTKYRNPSLKLLVNICGHSLCENCVDLLFARgsgsCPECNTALR 54
gi 321478367   8 CPKCKTTKYRNPAMILMVNACGHALCESCVELLFAKgsgaCPECKCPLR 56
gi 313219370   7 CPRCKTTSYRNPSMKLMINVCGHSLCESCVNLQYARgqapCYECALNLK 55
gi 215504048   6 CPRCRTTKYRNPSLKLMVNVCGHALCENCVELLFVKgsgsCPQCNVPLR 54
gi 229295593  81 CPRCKTTKYRNPSMVLMVNTCGHTLCENCVETLFARgsgtCPECNISLR 129
gi 761905276   6 CPRCKTSSYQNPNMKLLVNICGHKLCESCVESLFIRpsgpCPECGVALR 54
gi 195996905   9 CLGCKTSSYQNPKLKFLVNACGHRLCDGCIKAMFVRpsapCPQCGTILK 57
gi 918999343   6 CPRCRTTKYRNPSLKLMVNICGHTLCETCVDLLFIRgsgaCPECGTALR 54

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