5ZI6


Conserved Protein Domain Family
RING-HC_MEX3
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cd16518: RING-HC_MEX3 
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RING finger, HC subclass, found in RNA-binding proteins of the evolutionarily-conserved MEX-3 family
MEX-3 phosphoproteins are found in vertebrates. They are mediators of post-transcriptional regulation in different organisms, and have been implicated in many core biological processes, including embryonic development, epithelial homeostasis, immune responses, metabolism, and cancer. They contain two K homology (KH) domains that provide RNA-binding capacity, and a C-terminal C3HC4-type RING-HC finger. They shuttle between the nucleus and the cytoplasm via the CRM1-dependent export pathway. The RNA-binding protein MEX-3 from nematode Caenorhabditis elegans is the founding member of the MEX-3 family. Due to the lack of a RING-HC finger, it is not included here.
Links
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Statistics
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PSSM-Id: 438181
Aligned: 16 rows
Threshold Bit Score: 75.8678
Created: 2-May-2013
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Structure:5ZI6; Homo sapiens MEX3C binds two Zn2+ ions
    - View structure with Cn3D
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #           # #   #  #                      #  #           
5ZI6_A         2 HDCVICFENEVIAALVPCGHNLFCMECANKICekr-----------tpSCPVCQTAVTQAIQIH 54  human
ABC86136     437 KQCMVCSDNEIVAALVPCGHNLFCMECANSLInke-----------naPCPMCHEPVTQAIRIQ 489 common urchin
AAY54992     604 RECFVCNENTVTTALVPCGHNMFCMECANHIClsm-----------daVCPVCNSIVYHAMRIL 656 fruit fly
EFX83468      32 RECIMCCEGEMVAALVPCGHKLFCMDCAQRLVpkessaesdspssaggECPVCHQSVTQAIRIF 95  common water flea
XP_013380853 494 RSCFVCSDSDVVAALVPCGHNLFCMECANLIVekpd---------tkrRCPICQQVPTQAIRII 548 Lingula anatina
KFM77326     456 RECVMCYESAIVAALVPCGHNLFCMECANRICeks-----------gsECPECHTPASQAIRIY 508 Stegodyphus mimosarum
XP_017210005 532 RDCYVCCESEVTAALVPCGHNLFCMDCAGQICqss-----------daECPVCHTPATQCIRIF 584 zebrafish
Q86XN8       598 RECVVCAEGEVMAALVPCGHNLFCMDCAVRICgks-----------epECPACRTPATQAIHIF 650 human
KPP70301     532 KDCFVCYESEVTAALVPCGHKLFCMDCAGQICqsg-----------epKCPVCHTPATQCIRVF 584 Asian bonytongue
XP_002730746 475 KECMMCFESEVVAALVPCGHNLFCMECANRLMeks-----------dpECPVCHQTITQAIRIF 527 Saccoglossus kowalevskii

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