Conserved Protein Domain Family
RING-HC_MEX3

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cd16518: RING-HC_MEX3 
RING finger, HC subclass, found in RNA-binding proteins of the evolutionarily-conserved MEX-3 family
The family includes MEX-3 family phosphoproteins have been found in vertebrates. They are mediators of post-transcriptional regulation in different organisms, and have been implicated in many core biological processes, including embryonic development, epithelial homeostasis, immune responses, metabolism, and cancer. They contain two K homology (KH) domains that provide RNA-binding capacity, and a C-terminal C3HC4-type RING-HC finger. They shuttle between the nucleus and the cytoplasm via the CRM1-dependent export pathway. The RNA-binding protein MEX-3 from nematode Caenorhabditis elegans is the founding member of the MEX-3 family. Due to the lack of RING-HC finger, it is not included here.
Statistics
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PSSM-Id: 319432
View PSSM: cd16518
Aligned: 17 rows
Threshold Bit Score: 55.8357
Threshold Setting Gi: 321472498
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus Hakai (3VK6) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
Feature 1        #  #           # #   #  #             #  # 
gi 134047829 600 CVVCAEgevmAALVPCGHNLFCMDCAVRIcgks--epeCPACR 640
gi 85838460  439 CMVCSDneivAALVPCGHNLFCMECANSLinke--napCPMCH 479
gi 405957283 484 CLMCSDseivAALVPCGHNLFCMECANLIvekpareriCPVCN 526
gi 66771361  606 CFVCNEntvtTALVPCGHNMFCMECANHIclsm--davCPVCN 646
gi 134047827 608 CVICFEneviAALVPCGHNLFCMECANKIcekr--tpsCPVCQ 648
gi 22759735  521 CVMCNEgsvmAALVPCGHNLFCYECAQKAass---sahCPCCN 560
gi 919087537 496 CFVCSDsdvvAALVPCGHNLFCMECANLIvekpdtkrrCPICQ 538
gi 585645368 477 CMMCFEsevvAALVPCGHNLFCMECANRLmeks--dpeCPVCH 517
gi 675384429 458 CVMCYEsaivAALVPCGHNLFCMECANRIceks--gseCPECH 498
gi 229295214 437 CMICYEsevvAALVPCGHNLFCMECANRLcekk--daeCPVCH 477

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