Conserved Protein Domain Family
RING-HC_MIBs_like

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cd16520: RING-HC_MIBs_like 
RING finger, HC subclass, found in mind bomb MIB1, MIB2, RGLG1, RGLG2, and similar proteins
MIBs are large, multi-domain E3 ubiquitin-protein ligases that promote ubiquitination of the cytoplasmic tails of Notch ligands. They are also responsible for TBK1 K63-linked ubiquitination and activation, promoting interferon production and controlling antiviral immunity. Moreover, MIBs selectively control responses to cytosolic RNA and regulate type I interferon transcription. Both MIB1 and MIB2 have similar domain architectures, which consist of two Mib-Herc2 domains flanking a ZZ zinc finger, a REP region including two tandem Mib repeats, an ANK region that spans ankyrin repeats, and a RNG region, where MIB1 and MIB2 contain three and two C3HC4-type RING-HC fingers, respectively. This family corresponds to the third RING-HC finger of MIB1, as well as the second RING-HC finger of MIB2. In addition to MIB1 and MIB2, RING domain ligase RGLG1, RGLG2 and similar proteins from plant have also been included in this family. RGLG1 is a ubiquitously expressed E3 ubiquitin-protein ligase that interacts with UBC13 and, together with UBC13, catalyzes the formation of K63-linked polyubiquitin chains, which is involved in DNA damage repair. RGLG1 mediates the formation of canonical, K48-linked polyubiquitin chains that target proteins for degradation. It also regulates apical dominance by acting on the auxin transport proteins abundance. RGLG1 has overlapping functions with its closest sequelog, RGLG2. They both function as RING E3 ligases that interact with ethylene response factor 53 (ERF53) in the nucleus and negatively regulate the plant drought stress response. All RGLG proteins contain a Von Willebrand factor type A (vWA) domain and a C3HC4-type RING-HC finger.
Statistics
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PSSM-Id: 319434
View PSSM: cd16520
Aligned: 11 rows
Threshold Bit Score: 69.7214
Threshold Setting Gi: 32565608
Created: 5-Jan-2016
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens Parkin (5C1Z) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30
                  ....*....|....*....|....*....|....*....
Feature 1          #  #          # #  #  #       #  #    
gi 209572707  968 TCPICIdshIRLVFQCGHGACAPCGSALs-aCPICRQPI 1005
gi 75207472   445 LCPICLsnpKNMAFGCGHQTCCECGPDLk-vCPICRAPI 482
gi 68565512   962 MCPVCLdrlKNMIFLCGHGTCQLCGDRMs-eCPICRKAI 999
gi 262099518  387 LCPICEdrkKDTVFQCGHETCQKCGEFLs-hCPLCRQQI 424
gi 918291049  728 TCPICMdrpRNMAFECGHTVCKECGESLk-eCHMCSKPI 765
gi 585659370  506 CCPICMettRDVAFQCGHMTCRKCSELIh-kCPICRTAI 543
gi 780045409 1300 LCPICMenkRNVVFLCGHSVCKKCSRPLk-qCPLCRKPI 1337
gi 919028096  884 MCSICLdrkKDLVFLCGHSACHICAQPLr-nCHMCRKPI 921
gi 391326093  897 SCSICMerkRNVAFLCGHAACAKCAAPLk-tCHMCRKPI 934
gi 20129611  1005 FCGICMerkRDVAFLCGHGACSHCAETLr-tCHMCRKTI 1042
gi 32565608   719 NCAICMdlkIAVVFNCGHTACVDCADKLkkqCHICRKTI 757

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