Conserved Protein Domain Family
RING-HC_MKRN

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cd16521: RING-HC_MKRN 
RING finger, HC subclass, found in the makorin (MKRN) protein family
The MKRN protein family includes the ribonucleoproteins that are characterized by a variety of zinc-finger motifs, including typical arrays of one to four C3H1-type zinc fingers and a C3HC4-type RING-HC finger. Another motif rich in Cys and His residues (CH), with so far unknown function, is also generally present in MKRN proteins. MKRN proteins may have E3 ubiquitin ligase activity.
Statistics
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PSSM-Id: 319435
View PSSM: cd16521
Aligned: 34 rows
Threshold Bit Score: 63.875
Threshold Setting Gi: 18424150
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens RNF144A (1WIM) binds two Zn2+ ions through its C4C4-type RING finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1        #  #                         # #  #  #                              #  # 
gi 67477468  281 CGICMEvvyek-----anpseRRFGILSNCNHTYCLKCIRKWRsakqf-------------eskiiKSCPECR 335
gi 158273898 168 CGICLEhvmhk------psvsDRRFGLMDCDHAFCLACIRSWRerntdas---------latdtavRTCPICR 225
gi 692169519 532 CGICLEplp---------vngITKFGLLNCNHPFCLECIRSWRasqnv-------------dssicRSCPICR 582
gi 569418628 240 CGICHEniarkyesqghkdnaGRFGILTGCNHTFCLNCLREWRgsisq-------------skeaiRGCPICR 299
gi 428169132 203 CGICMEtvv---------gkqSQFGLLEGCDHIFCLSCIREWRsvnil-------------eknvkRSCPLCR 253
gi 531983775 100 CGICMEt-------------pTVFGLLVNCDHVFCLSCIRSWRssvgtsaedmintpdsrvprqttKTCPLCR 159
gi 443708066 169 CCLCEEpv-----------krTLFGMLSHCNHVFCVECLRGWRcapgr-------------ehmlkRTCPKCR 217
gi 752368713 119 CGICFEv-------------pGQFGLLNGCSHPFCLNCLRDWRksskkdih--------lvfsniiKTCPLCR 170
gi 18424150  144 CGICMEm--------------NSKVVLPNCTHSLCIKCYRDWRgr--------------------sQSCPFCR 182
gi 970646426  44 CGICFDdiv----------qsGKHFGLLHCDHCFCLDCLRSWRqskdm-------------eleviRACPACR 93

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