4B7Y


Conserved Protein Domain Family
RING-HC_MSL2

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cd16522: RING-HC_MSL2 
Click on image for an interactive view with Cn3D
RING finger found in Drosophila melanogaster male-specific lethal-2 (MSL2) and similar proteins
MSL2, also known as RING finger protein 184 (RNF184), is a putative DNA-binding protein required for X chromosome dosage compensation in Drosophila males. Its expression is sex specifically regulated by Sex-lethal. Drosophila dosage compensation proteins MOF, MSL1, MSL2, and MSL3 are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). MSL2 plays a critical role in translation and/or stability of MSL1 in males. In complex with MSL1, it acts as an E3 ubiquitin ligase that promotes ubiquitination of histone H2B. MSL2 contains a C3HC4-type RING-HC finger and a metallothionein-like domain with eight conserved and two non-conserved cysteines, as well as a positively and a negatively charged amino acid residue cluster and a coiled coil domain that may be involved in protein-protein interactions. This family also includes many male-specific lethal-2 homologs from bilaterians.
Statistics
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PSSM-Id: 319436
View PSSM: cd16522
Aligned: 15 rows
Threshold Bit Score: 68.1947
Threshold Setting Gi: 443715680
Created: 13-Nov-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteRING-HC finger
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
Feature 1          #  #              # #  #  #          #  #  
4B7Y_C        42 LSCCVCGHLLqdpiaPTNSTCQHYVCKTCKGKKMmMKPSCSWCKD 86
gi 254028201  42 LACLVCGNLLqdpiaPTNSSCQHYVCKSCKGKKMmMKPSCSWCKD 86
gi 301621240  42 LACCVCGKLLedpiaPINSTCQHYVCKQCKGKKMmMKPSCSWCKD 86
gi 780122949  39 LSCCVCGSLLndplgPTDSNCQHFVCRTCVGGKMlLKPTCSWCKN 83
gi 585669546  39 LSCCVCTSLIsdpmgPTESICQHHVCRSCLGGKMrLRPSCSWCKD 83
gi 919076004  39 LLCYVCGGILqrpmgPVEKVCQHNVCNDCVGGKMrLKPQCSWCKD 83
gi 918307379  35 LSCCVCGQLLrrpcgPEPNVCQHFVCTGCVGGKMnLKPSCSWCKD 79
gi 321458435  39 LSCTVCDLLLve-pySPESSCQHHVCKSCRGRKKkLKPSCSWCKC 82
gi 443715680  39 LTCCVCGLIIyhaigPAHSACMHHVCEGCRDGKMrLRPACGWCGD 83
gi 675389109  39 LLCCVCGKLMvipmrSNMAHCQHNVCKHCIGGQMrLHPQCVWCLD 83

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