Conserved Protein Domain Family
RING-HC_PEX2

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cd16526: RING-HC_PEX2 
RING finger, HC subclass, found in peroxin-2 (PEX2) and similar proteins
PEX2, also known as peroxisome biogenesis factor 2, 35 kDa peroxisomal membrane protein, peroxisomal membrane protein 3, peroxisome assembly factor 1 (PAF-1), or RING finger protein 72 (RNF72), is an integral peroxisomal membrane protein with two transmembrane regions and a C3HC4-type RING-HC finger within its cytoplasmically exposed C-terminus. It may be involved in the biogenesis of peroxisomes, as well as in peroxisomal matrix protein import. Mutations in the PEX2 gene are the primary defect in a subset of patients with Zellweger syndrome and related peroxisome biogenesis disorders. Moreover, PEX2 functions as an E3-ubiquitin ligase that mediates the UBC4-dependent polyubiquitination of PEX5, a key player in peroxisomal matrix protein import, to control PEX5 receptor recycling or degradation.
Statistics
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PSSM-Id: 319440
View PSSM: cd16526
Aligned: 35 rows
Threshold Bit Score: 42.3735
Threshold Setting Gi: 74625915
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens TFIIH MAT1 subunit (1G25) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #  #                                                   #  #  #  #              
gi 281185478  243 ECALCGEWPt----------------------------------------mPHTIGC-EHIFCYFCAKssfl-------- 273
gi 262111387  270 QCCLCGISPpq---------------------------------------tPYITSC-KHVYCYYCLQtava-------- 301
gi 428175959  278 ACNLCGSEPan---------------------------------------sPHSGAC-GHVYCYYCLSsllhd------- 310
gi 765551691  291 PCGICGESPig---------------------------------------tPSVVPC-GHVYCYVCIAsncl-------- 322
gi 2501728    280 VCAICFQNSqnsdsgaqnd----------------------islndtlvtnPYETTC-GHIYCYVCILsklqifkeegkn 336
gi 827756536  285 QCAICADNAsfnlssfandpghfasglerssgqqaevaseeggppnfpitsTYRASC-GHEYCYYCLAgrllrav----- 358
gi 930437486  956 LCPLCGQQPs----------------------------------------nPYVTSC-LHIYCFACLNqvayesm----- 989
gi 198419568  228 KCSYCNKVPi----------------------------------------mPHTSNCeIHAHCYYCVAsslv-------- 259
gi 761907687  227 VCVYCNGVPv----------------------------------------lPQVSTC-RHLFCYYCIAanvl-------- 257
gi 322518685   17 ECVKCKKPRgd--------------------------------------lqYLGSSC-KHAYCWECIAtfqqkpsg---- 53
                          90
                  ....*....|....*.
Feature 1                    #  # 
gi 281185478  274 -----fdvyFTCPKCG 284
gi 262111387  302 -----teddFACVACG 312
gi 428175959  311 -----aidtARCKRCH 321
gi 765551691  323 -----adsgYRCLRCN 333
gi 2501728    337 lpksdpnkyWHCLRCN 352
gi 827756536  359 ---ddgddgWECLRCT 371
gi 930437486  990 ---vaggesATCLECS 1002
gi 198419568  260 -----knskCECPSCH 270
gi 761907687  258 -----adsnFPCPVCN 268
gi 322518685   54 --krssvarHMCPSCA 67

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