Conserved Protein Domain Family
RING-HC_PEX10

?
cd16527: RING-HC_PEX10 
RING finger, HC subclass, found in peroxin-10 (PEX10) and similar proteins
PEX10, also known as peroxisome biogenesis factor 10, peroxisomal biogenesis factor 10, peroxisome assembly protein 10, or RING finger protein 69 (RNF69), is an integral peroxisomal membrane protein with two transmembrane regions and a C3HC4-type RING-HC finger within its cytoplasmically exposed C-terminus. It plays an essential role in peroxisome assembly, import of target substrates, and recycling or degradation of protein complexes and amino acids. It is an essential component of the spinal locomotor circuit, and thus its mutations may be involved in peroxisomal biogenesis disorders (PBD). Mutations in human PEX10 also result in autosomal recessive ataxia. Moreover, PEX10 functions as an E3-ubiquitin ligase with an E2, UBCH5C. It mono- or poly-ubiquitinates PEX5, a key player in peroxisomal matrix protein import, in a UBC4-dependent manner, to control PEX5 receptor recycling or degradation. It also links the E2 ubiquitin conjugating enzyme PEX4 to the protein import machinery of the peroxisome.
Statistics
?
PSSM-Id: 319441
View PSSM: cd16527
Aligned: 37 rows
Threshold Bit Score: 59.9228
Threshold Setting Gi: 428164097
Created: 3-May-2013
Updated: 18-Aug-2016
Structure
?
Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens BRCA1 (1JM7) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
Feature 1         #  #           # #  #  #               #  # 
gi 3914299   272 LCTLCLEERrhPTATPCGHLFCWECITAWCss-----kaECPLCR 311
gi 284092717 363 KCCLCLERRvkTTATMCGHLYCWDCITECVsns---kepKCPICR 404
gi 910755899 255 KCILCLESIreATSTGCGHLYCWDCIVEYCvqtkpplvpFCPLCR 299
gi 761901434 230 KCSLCLENCtcPTVPPCGHLYCWSCIIEWVse-----kgNCPLCR 269
gi 190584185 244 KCCLCLESCqhPTCTPCGHIFCWHCIAGWCrt-----kpECPLCR 283
gi 51701860  255 KCSLCMEFIhcPAATECGHIFCWSCINGWTsk-----ksECPLCR 294
gi 358056200 386 RCTLCLGPRrdPASTECGHTFCWECIVGWAre-----kpECPLCR 425
gi 215506034 214 SCCMCVDGArrPTVIPCGHVFCWYCIAGWLra-----kkECPLCR 253
gi 158272629 155 QCPLCLSPKshPASTPCGHTFCWSCIATWCge-----kpECPLCR 194
gi 28925975  376 MCTLCLEELkdPAATQCGHVFCWSCIGDWVre-----kpECPLCR 415

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap