4R8P


Conserved Protein Domain Family
RING-HC_RING1_like

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cd16531: RING-HC_RING1_like 
Click on image for an interactive view with Cn3D
RING finger, HC subclass, found in really interesting new gene proteins RING1, RING2 and similar proteins
RING1, also known as polycomb complex protein RING1, RING finger protein 1 (RNF1), or RING finger protein 1A (RING1A), was identified as a transcriptional repressor that is associated with the Polycomb group (PcG) protein complex involved in stable repression of gene activity. RING2, also known as huntingtin-interacting protein 2-interacting protein 3, HIP2-interacting protein 3, protein DinG, RING finger protein 1B (RING1B), RING finger protein 2 (RNF2), or RING finger protein BAP-1, is an E3 ubiquitin-protein ligase that interacts with both nucleosomal DNA and an acidic patch on histone H4 to achieve the specific monoubiquitination of K119 on histone H2A (H2AK119ub), thereby playing a central role in histone code and gene regulation. Both RING1 and RING2 are core components of polycomb repressive complex 1 (PRC1) that functions as an E3-ubuiquitin ligase transferring the mono-ubuiquitin mark to the C-terminal tail of Histone H2A at K118/K119. PRC1 is also capable of chromatin compaction, a function not requiring histone tails, and this activity appears important in gene silencing. RING2 acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. Members in this family contain a C3HC4-type RING-HC finger.
Statistics
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PSSM-Id: 319445
View PSSM: cd16531
Aligned: 25 rows
Threshold Bit Score: 65.9163
Threshold Setting Gi: 302754330
Created: 3-May-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
Feature 1         #  #            # #  #  #           #  # 
4R8P_L         51 CPICLDMLknTMTTKECLHRFCADCIITALRsGNKECPTCR 91
gi 919023186   47 CPICLDMLknTMTTKECLHRFCQECIITALRsGNKECPTCR 87
gi 302425246  136 CPICLGIIkkTRTVMECLHRFCRECIDKSMRlGNNECPACR 176
gi 294462674   66 CPICLGIIrkTRTVMECLHRFCRDCIDKSMRlGNNECPACR 106
gi 551669543   27 CAICMNIIseTTIITDCLHRFCADCITQCLRhSKRECPSCR 67
gi 302754330   14 CPICLGIIrkTRTVMECLHRFCRECIDKSMRlGNNECPACR 54
gi 262102505   77 CPICLGIIkeTMVVMECLHRFCGECISTAIRhSNRECPSCR 117
gi 557736616  650 CPICMGIFqnVVVVKDCLHRFCADCIEKCVRtGLRECPQCR 690
gi 168065332    3 CPICLGIIrkTRTVMECLHRFCRECIDKSMRlGNNECPACR 43
gi 765548162   56 CPVCLCLIqnAHGNIECLHRFCEECITSAVRmGPKQCPSCR 96

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