4PPE,2XEU,3NG2,4AP4,2EA6,4AP4


Conserved Protein Domain Family
RING-HC_RNF4

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cd16533: RING-HC_RNF4 
Click on image for an interactive view with Cn3D
RING finger, HC subclass, found in RING finger protein 4 (RNF4) and similar proteins
RNF4, also known as small nuclear ring finger protein (SNURF), is a SUMO-targeted E3 ubiquitin-protein ligase with a pivotal function in the DNA damage response (DDR) through interacting with the deubiquitinating enzyme ubiquitin-specific protease 11 (USP11), a known DDR-component, and further facilitating DNA repair. It plays a novel role in preventing the loss of intact chromosomes and ensures the maintenance of chromosome integrity. Moreover, RNF4 is responsible for the UbcH5A-catalyzed formation of K48 chains that target SUMO-modified promyelocytic leukemia (PML) protein for proteasomal degradation in response to arsenic treatment. It also interacts with telomeric repeat binding factor 2 (TRF2) in a small ubiquitin-like modifiers (SUMO)-dependent manner and preferentially targets SUMO-conjugated TRF2 for ubiquitination through SUMO-interacting motifs (SIMs). Furthermore, RNF4 can form a complex with a Ubc13-ubiquitin conjugate and Ube2V2. It catalyzes K63-linked polyubiquitination by the Ube2V2-Ubc13 (ubiquitin-loaded) complex. Meanwhile, RNF4 negatively regulates nuclear factor kappa B (NF-kappaB) signaling by down-regulating transforming growth factor beta (TGF-beta)-activated kinase 1 (TAK1)-TAK1-binding protein2 (TAB2). RNF4 contains four SIMs followed by a C3HC4-type RING-HC finger at the C-terminus.
Statistics
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PSSM-Id: 319447
View PSSM: cd16533
Aligned: 16 rows
Threshold Bit Score: 85.5878
Threshold Setting Gi: 159164353
Created: 26-Jul-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:4AP4; Rattus norvegicus RNF4 binds four Zn2+ ions through its two RING-HC fingers.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
Feature 1             #  #                  # #  #  #          #  #    
4PPE_A        13 SGTVSCPICMDGYSEIVQNGRLIVSTECGHVFCSQCLRDSLKNaNTCPTCRKKI 66
4AP4_A        70 SGTVSCPICMDGYSEIVQNGRLIVSTECGHVFCSQCLRDSLKNaNTCPTCRKKI 123
2EA6_A        13 SGTVSCPICMDGYSEIVQNGRLIVSTECGHVFCSQCLRDSLKNaNTCPTCRKKI 66
4AP4_A         5 SGTVSCPICMDGYSEIVQNGRLIVSTECGHVFCSQCLRDSLKNaNTCPTCRKKI 58
gi 229366630 145 PVTISCPVCLDSYSEIVESGRLVVSTICGHVFCSQCLRDALKSsHTCPTCRKRL 198
gi 632974006 145 PGTISCPICLDNYTEIVQSGRLIVSTKCGHVFCSQCIRDSLKNaQTCPTCRVKL 198
gi 918997895 152 RSAVSCPICMDNEMQIKASGRQLQSTVCGHIFCNVCIRCSIQTsKKCPTCRKKL 205
gi 449684861 179 KTSVTCSVCLDNLDQISSDGRKLTSTICGHIFCDECILKAVKTiHSCPTCRMKL 232
gi 585662429 265 RRCITCPVCMDDEKQIKSNRRHLVSTVCGHIFCNKCIVGAIQSqHRCPACRKKI 318
gi 390338891 187 KRVITCPICMEDETTLRNNGQQLMSTNCGHVFCRHCIRASIQTqHRCPTCRKKL 240

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