Conserved Protein Domain Family
RING-HC_RNF5_like

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cd16534: RING-HC_RNF5_like 
RING finger, HC subclass, found in RING finger protein RNF5, RNF185 and similar proteins
RNF5 and RNF185 are E3 ubiquitin-protein ligases that are anchored to the outer membrane of the endoplasmic reticulum (ER). RNF5 acts at early stages of cystic fibrosis (CF) transmembrane conductance regulator (CFTR) biosynthesis, and functions as a target for therapeutic modalities to antagonize mutant CFTR proteins in CF patients carrying the F508del allele. RNF185 controls the degradation of CFTR and CFTR F508del allele in a RING- and proteasome-dependent manner, but does not control that of other classical endoplasmic reticulum-associated degradation (ERAD) model substrates. Moreover, both RNF5 and RNF185 play important roles in cell adhesion and migration through the modulation of cell migration by ubiquitinating paxillin. Arabidopsis thaliana RING membrane-anchor proteins (AtRMAs) are also included in this family. They possess E3 ubiquitin-protein ligase activity and may play a role in the growth and development of Arabidopsis. All members in this family contain a C3HC4-type RING-HC finger.
Statistics
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PSSM-Id: 319448
View PSSM: cd16534
Aligned: 12 rows
Threshold Bit Score: 62.8348
Threshold Setting Gi: 968582680
Created: 3-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens BRCA1 (1JM7) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
Feature 1          #  #           # #  #  #                    #  # 
gi 74751883    38 ECNICLDTakDAVISLCGHLFCWPCLHQWLetrp-------nrqvCPVCK 80
gi 74762702    26 ECNICLETarEAVVSVCGHLYCWPCLHQWLetrp-------erqeCPVCK 68
gi 470293625    3 ECNICLDTadDAVISLCGHLYCWPCLHRWLelha-------drplCPVCK 45
gi 360043086   41 ECNICLDSaqDAVVSMCGHLFCWPCLHRWLetae-------trtvCPVCK 83
gi 340378539   23 ECNICFDTatNAVVSMCGHLFCWPCIHTWMearpq------dtptCPVCK 66
gi 24664494    17 ECNICLDTaqNAVVSMCGHLFCWPCLYQWIltkp-------dhtvCPVCK 59
gi 183234591   64 ECLICLDTaqNAVVTQCGHMFCWECLREWLtrq----------etCPICK 103
gi 934161739   40 DCNICLDTakDAVVSICGHLFCWPCLHQWFetkp-------vrptCPVCK 82
gi 954376527 1015 ECNICLETarEAVISMCGHLFCWSCLHQWFetrp-------anpiCPVCK 1057
gi 75328843    43 DCNICLDTahDPVVTLCGHLFCWPCIYKWLhvqlssvsvdqhqnnCPVCK 92
gi 968582680   23 QCSICLDApkDLSATPCGHLFCYACIHQALssa---------gatCPICR 63
gi 528298205  221 QCIICMDSptDLTVTHCGHLFCSECLHQALhage--------kkcCPVCR 262

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