Conserved Protein Domain Family
RING-HC_RNF37

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cd16537: RING-HC_RNF37 
RING finger, HC subclass, found in RING finger protein 37 (RNF37)
RNF37, also known as KIAA0860, U-box domain-containing protein 5 (UBOX5), UbcM4-interacting protein 5 (UIP5), or ubiquitin-conjugating enzyme 7-interacting protein 5, is an E3 ubiquitin-protein ligase found exclusively in the nucleus as part of a nuclear dot-like structure. It interacts with the molecular chaperone VCP/p97 protein. RNF37 contains a U-box domain followed by a potential nuclear location signal (NLS) and a C-terminal C3HC4-type RING-HC finger. The U-box domain is a modified RING finger domain that lacks the hallmark metal-chelating cysteines and histidines of the latter, and is likely to adopt a RING finger-like conformation. The presence of the U-box, but not of the RING finger, is required for the E3 activity. The U-box domain can directly interact with several E2 enzymes, including UbcM2, UbcM3, UbcM4, UbcH5, and UbcH8, suggesting a similar function as the RING finger in the ubiquitination pathway. This family corresponds to the RING-HC finger.
Statistics
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PSSM-Id: 319451
View PSSM: cd16537
Aligned: 6 rows
Threshold Bit Score: 79.854
Threshold Setting Gi: 642085895
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus Hakai (3VK6) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
Feature 1         #  #                 # #  #  #                  #  # 
gi 21363047  482 ECASCKRVFSPYfkkepvYQLPCGHLLCRPCLGEKQRslp-------mtCTACQ 528
gi 483524123 458 GCASCGKTFSPYfktepvYQLPCGHLLCRPCLAEKQKapa-------vaCGSCK 504
gi 147902180 481 GCSSCGRIFSAYcktepvYQLSCGHLMCRPCLAEKQKsls-------vlCNNCN 527
gi 166987260 410 GCAVCSKAFSPYfkaeavYRFPCGHLMCRPCLTQRQQssl-------imCVGCE 456
gi 224016236 401 VCIACCRAFSAYcsylviYRLPCGHLICRPCLSERQKtaa-------lsCLKCN 447
gi 642085895 544 RCGSCSCSLSVYstspsaYRLPCGHFLCRPCLHRKSRplvttampnhilCPTCH 597

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