2ECN


Conserved Protein Domain Family
RING-HC_RNF141

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cd16545: RING-HC_RNF141 
Click on image for an interactive view with Cn3D
RING finger, HC subclass, found in RING finger protein 141 (RNF141) and similar proteins
RNF141, also known as zinc finger protein 230 (ZNF230), is a RING finger protein present primarily in the nuclei of spermatogonia, the acrosome, and the tail of spermatozoa. It may have a broad function during early development of vertebrates. It plays an important role in spermatogenesis, including spermatogenic cell proliferation and sperm maturation, as well as motility and fertilization. It also exhibits DNA binding activity. RNF141 corresponding ZNF230 gene mutation may be associated with azoospermia. RNF141 contains a C3HC4-type RING finger domain that may function as an activator module in transcription.
Statistics
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PSSM-Id: 319459
View PSSM: cd16545
Aligned: 17 rows
Threshold Bit Score: 69.3553
Threshold Setting Gi: 734557780
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteRING-HC finger
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:2ECN; Homo sapiens RNF141 binds two Zn2+ ions through its RING-HC finger.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
Feature 1         #  #          # #  #  #           #  # 
2ECN_A        17 ECCICMDgraDLILPCAHSFCQKCIDKWSdrh-rnCPICR 55
gi 443710077 147 ECCICMDrkaGIILPCAHVYCEQCIDAWNvnh-ntCPICR 185
gi 156227925 159 ECCICMEqqsEIILACVHSFCKSCIDRWSdsh-ntCPICR 197
gi 405965318 197 ECCICMErrsEIILPCTHQFCEGCIDTWNvtn-ktCPICR 235
gi 215495799  64 ECCVCMErkpEVTLPCTHSYCLFCIEQWNvsn-ttCPLCR 102
gi 74751546  154 ECCICMDgraDLILPCAHSFCQKCIDKWSdrh-rnCPICR 192
gi 919058053 151 ECIICMErkaDVILPCAHLYCEQCIDRWSvss-htCPVCR 189
gi 585699654 157 ECCICMDartDIILTCNHMYCEKCIDKWNvnh-hqCPICR 195
gi 952528581 153 VCCICFDrktEVLLPCTHSYCLICIEEWNedh-dtCPVCR 191
gi 734557780 133 ECIICMErapDTILPCAHSYCLVCIEQWKaygkslCPVCR 172

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