2ECN,5XEK


Conserved Protein Domain Family
RING-HC_RNF141
?
cd16545: RING-HC_RNF141 
Click on image for an interactive view with Cn3D
RING finger, HC subclass, found in RING finger protein 141 (RNF141) and similar proteins
RNF141, also known as zinc finger protein 230 (ZNF230), is a RING finger protein present primarily in the nuclei of spermatogonia, the acrosome, and the tail of spermatozoa. It may have a broad function during early development of vertebrates. It plays an important role in spermatogenesis, including spermatogenic cell proliferation and sperm maturation, as well as motility and fertilization. It also exhibits DNA binding activity. RNF141/ZNF230 gene mutations may be associated with azoospermia. RNF141 contains a C3HC4-type RING finger domain that may function as an activator module in transcription.
Links
?
Statistics
?
PSSM-Id: 438207
Aligned: 15 rows
Threshold Bit Score: 60.1819
Created: 2-May-2013
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Structure:2ECN; Homo sapiens RNF141 binds two Zn2+ ions through its RING-HC finger.
    - View structure with Cn3D
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #          # #  #  #          #  # 
2ECN_A        16 EECCICMDGRaDLILPCAHSFCQKCIDKWSdrHRNCPICR 55  human
5XEK_A         2 EECCICMDGRaDLILPCAHSFCQKCIDKWSdrHRNCPICR 41  human
XP_005989755 163 EECCICMDGRaDLILPCAHSFCQKCIDKWSdrNRNCPICR 202 coelacanth
XP_007907530 155 EECCICMDGRaDLILPCAHSFCQKCIDKWSdrNRNCPICR 194 elephant shark
ELU04440     146 SECCICMDRKaGIILPCAHVYCEQCIDAWNvnHNTCPICR 185 Capitella teleta
EDO48726     158 EECCICMEQQsEIILACVHSFCKSCIDRWSdsHNTCPICR 197 starlet sea anemone
EEC05440      63 EECCVCMERKpEVTLPCTHSYCLFCIEQWNvsNTTCPLCR 102 black-legged tick
Q8WVD5       153 EECCICMDGRaDLILPCAHSFCQKCIDKWSdrHRNCPICR 192 human
XP_006812631 156 SECCICMDARtDIILTCNHMYCEKCIDKWNvnHHQCPICR 195 Saccoglossus kowalevskii
KRT82390     152 TVCCICFDRKtEVLLPCTHSYCLICIEEWNedHDTCPVCR 191 Oryctes borbonicus

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap