4QPL,2D8T


Conserved Protein Domain Family
RING-HC_RNF146

?
cd16546: RING-HC_RNF146 
Click on image for an interactive view with Cn3D
RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
RNF146, also known as dactylidin, or iduna, is a cytoplasmic E3 ubiquitin-protein ligase that is responsible for PARylation-dependent ubiquitination (PARdU). It displays neuroprotective property due to its inhibition of Parthanatos, a PAR dependent cell death, via binding with Poly(ADP-ribose) (PAR). It also modulates PAR polymerase-1 (PARP-1)-mediated oxidative cell injury in cardiac myocytes. Moreover, RNF146 mediates tankyrase-dependent degradation of axin, thereby positively regulates Wnt signaling. It also facilitates DNA repair and protects against cell death induced by DNA damaging agents or gamma-irradiation through translocating to the nucleus after cellular injury and promoting the ubiquitination and degradation of various nuclear proteins involved in DNA damage repair. Furthermore, RNF146 is implicated in neurodegenerative disease and cancer development. It regulates the development and progression of non-small cell lung cancer (NSCLC) by enhancing cell growth, invasion, and survival. RNF146 contains an N-terminal C3HC4-type RING-HC finger followed by a WWE domain with a poly(ADP-ribose) (PAR) binding motif at the tail.
Statistics
?
PSSM-Id: 319460
View PSSM: cd16546
Aligned: 20 rows
Threshold Bit Score: 55.0831
Threshold Setting Gi: 313243658
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
Feature 1         #  #           # #  #  #            #  # 
4QPL_A         7 ECAICLQtCVHPVSLPCKHVFCYLCVKGasw--lgKRCALCR 46
gi 82188480   41 ECPICLQsCVHPVRLPCRHIFCFLCVKGasw--hsKRCALCR 80
gi 156210131   2 DCPVCLQqASYPVRLPCGHMFCFLCIKGval--rsRKCAICR 41
gi 215507079  28 ECAICLQkCIHPAKLPCGHIFCYLCVKGian--qsKKCAMCR 67
gi 221513045 123 ECPICLQtCIHPARLPCGHIFCFLCVKGvay--knRRCAMCR 162
gi 313243658   5 SCPICLEdLLLPLTLPCSHKFCYLCIKGvalspsgPTCPLCR 46
gi 353231492   7 ECSICLQnLVHPAQLPCGHIFCFLCIKGcaf--hrRKCPMCR 46
gi 443696219 156 ECPICLQtCIHPVQLPCSHVFCFLCVKGgan--qsKRCALCR 195
gi 632962668  36 ECAICLQtCVHPVKLPCKHIFCFLCVKGasw--qsRRCALCR 75
gi 919079224  47 ECPVCLQtCVHPVKLPCNHIFCFLCVKGvan--qsKRCALCR 86

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap