Conserved Protein Domain Family
RING-HC_RNF166

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cd16549: RING-HC_RNF166 
RING finger, HC subclass, found in RING finger protein 166 (RNF166) and similar proteins
RNF166 is encoded by gene RNF166 targeted by thyroid hormone receptor alpha1 (TRalpha1), which is important in brain development. It plays an important role in RNA virus-induced interferon-beta production by enhancing the ubiquitination of TRAF3 and TRAF6. RNF166, together with three closely related proteins: RNF114, RNF125 and RNF138, forms a novel family of ubiquitin ligases with a C3HC4-type RING-HC finger, a C2HC-, and two C2H2-type zinc fingers, as well as a ubiquitin interacting motif (UIM).
Statistics
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PSSM-Id: 319463
View PSSM: cd16549
Aligned: 6 rows
Threshold Bit Score: 78.7165
Threshold Setting Gi: 585679268
Created: 3-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens BRCA1 (1JM7) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
Feature 1           #  #            # #  #  #           #  #    
gi 74762644   30 QYTCPICLEVYHRPVaiGSCGHTFCGECLQPCLQVpSPLCPLCRLPF 76
gi 47206993   41 QFSCPICLEVYHKPVsiASCAHTFCGECLQPCLQVtSPLCPLCRVPF 87
gi 110287943  34 QFGCPICLEVYYKPVaiGSCGHTFCGECLQPCLQVsSPLCPLCRMPF 80
gi 82075037   37 QFSCPICLEVFHRAVgiAGCGHTFCGECLQPCLQVpSPLCPLCRMPF 83
gi 557015734  56 QYSCPICLEVYYKPVsiTSCGHTFCGECLQPCLQVpSPLCPLCRMPF 102
gi 585679268  19 NFICSICLEVYRKPVt-ITCGHTFCRECLKPCIATaAPQCPVCRAAF 64

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