Conserved Protein Domain Family
RING-HC_RNF169

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cd16551: RING-HC_RNF169 
RING finger, HC subclass, found in RING finger protein 169 (RNF169) and similar proteins
RNF169 is an uncharacterized E3 ubiquitin-protein ligase paralogous to RNF168. It functions as a negative regulator of the DNA damage signaling cascade. RNF169 recognizes polyubiquitin structures but does not itself contribute to double-strand break (DSB)-induced chromatin ubiquitylation. It contributes to regulation of the DSB repair pathway utilization via functionally competing with recruiting repair factors, 53BP1 and RAP80-BRCA1, for association with RNF168-modified chromatin independent of its catalytic activity, limiting the magnitude of the RNF8/RNF168-dependent signaling response to DSBs. RNF169 contains an N-terminal C3HC4-type RING-HC finger and a C-terminal MIU (motif interacting with ubiquitin) domain.
Statistics
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PSSM-Id: 319465
View PSSM: cd16551
Aligned: 6 rows
Threshold Bit Score: 50.9775
Threshold Setting Gi: 2497083
Created: 30-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus Hakai (3VK6) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
Feature 1          #  #              #      #   #  #                  #  # 
gi 110287945   67 GCAGCLEpp---geAAALPC-----GH-SLCRGCAQraad-------aagpGCPRCR 107
gi 391359373   48 DCAGCLEtp---geAAALPC-----GH-SLCRGCAQraad-------aagpCCPRCR 88
gi 466058377   67 DCAGCLEtp---geAAALPC-----GH-SLCRGCAQraad-------aagpGCPRCR 107
gi 2497083    179 HCCICMEmek-gvrMIKLPCenanvEH-YLCRGCAKsyftamiqenrissvRCPQCE 233
gi 428161596   56 ECAVCMEma---knAILFPC-----GHqDLCIGCAEhikn--------nggTCPVCR 96
gi 442626417 2513 ECELCMNsypmnqmVSMLKC-----LH-KCCKQCAKsyftvqitdrsindcSCPFCK 2563

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