Conserved Protein Domain Family
RING-HC_RNF182

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cd16555: RING-HC_RNF182 
RING finger, HC subclass, found in RING finger protein 182 (RNF182) and similar proteins
RNF182 is a brain-enriched E3 ubiquitin-protein ligase that stimulates E2-dependent polyubiquitination in vitro. It is upregulated in the Alzheimer"s disease (AD) brains and neuronal cells exposed to injurious insults. It interacts with ATP6V0C and promotes its degradation by the ubiquitin-proteosome pathway, suggesting a very specific role in controlling the turnover of an essential component of neurotransmitter release machinery. RNF182 contains an N-terminal C3HC4-type RING-HC finger, and a C-terminal transmembrane domain.
Statistics
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PSSM-Id: 319469
View PSSM: cd16555
Aligned: 6 rows
Threshold Bit Score: 87.1167
Threshold Setting Gi: 465959157
Created: 26-Jul-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens transcription factor PML (1BOR) binds two Zn2+ ions through its RING-HC finger.
  • Citation:PMID 8317827
  • Citation:PMID 7729428

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
Feature 1         #  #               # #  #  #                #  #  
gi 74751050   19 ECKICYNRYnlkqRKPKVLECCHRVCAKCLYKIIDFGDSpqgVIVCPFCRF 69
gi 82236748   21 ECKICYNRYnlrqRKPKVLGCCHRVCAKCLYKLVDCGESpqcVIVCPFCRF 71
gi 465959157  22 ECKICYNRYdaraRKPKLLSCCHRVCAKCLRKMVAVGESsphLLSCPFCRQ 72
gi 632969026  21 ECKICYSPYnlrnRRPKVLECLHRVCGKCLYKIVDLGDSsssIICCPFCRY 71
gi 113679514  19 ECKICYCAYslssRRPKVLKCCHCLCAKCLAKIHDLGESspnAVICPFCRY 69
gi 557027106  21 ECKICYNRYnlrhRRPKVLECCHRVCSKCLCKIIDSGDSpqsVIVCPFCRF 71

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