Conserved Protein Domain Family
RING-HC_RNF183-like
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cd16556: RING-HC_RNF183-like 
RING finger, HC subclass, found in RING finger protein RNF183, RNF223, RNF225 and similar proteins
RNF183 is an E3 ubiquitin-protein ligase that is upregulated during intestinal inflammation and is negatively regulated by miR-7. It promotes intestinal inflammation by increasing the ubiquitination and degradation of inhibitor of kappa B, thereby resulting in secondary activation of the Nuclear factor-kappaB (NF-kB) pathway. The interaction between RNF183-mediated ubiquitination and miRNA may be an important novel epigenetic mechanism in the pathogenesis of inflammatory bowel disease (IBD). The biological function of RNF223 and RNF225 remains unclear. Members of this family contain an N-terminal C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438218
Aligned: 11 rows
Threshold Bit Score: 87.8097
Created: 5-Nov-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #               # #  #  #                   #  #       
E7ERA6        49 LECSICFSGYDNiFKTPKELSCTHVFCLECLARLaaaqpvgrpggeaVPCPFCRQPTAVP 108 human
XP_005162263  26 PECSICFNTYDNvFKTPKQLDCTHTFCLECLSRImttsmd--pqnskIPCPFCRQPTTIP 83  zebrafish
XP_005994526  25 ADCAICWSRYDNtFRTPKQLECQHSFCLECLARMslaava-eqtagrLPCPLCRHPTVLD 83  coelacanth
XP_007898380  10 PECVICWNRYDNaFRMPKVLECKHTFCLECLARMslafvs--esapeVSCPLCRQLTVLG 67  elephant shark
Q96D59        11 AECPVCWNPFNNtFHTPKMLDCCHSFCVECLAHLslvtp----arrrLLCPLCRQPTVLA 66  human
XP_018081457  22 LECSICFTKYDNiFKTPKLLQCSHTLCLECVARLvaalpp-ekqaedVLCPFCRQPTHIP 80  African clawed frog
XP_015152623  97 VECSICFNTYDNtFKTPKLLQCSHVFCLECVARLskglpp-nhpedqLPCPFCRQLTSIP 155 chicken
XP_007898555   9 LECTICFSDYNNgFRVPKVLECGHVFCLECLARMnmksh----vaeaILCPMCRGISQVP 64  elephant shark
XP_018084877  42 CDCPVCWNPYTPtFRTPKLLHCNHCFCMECLERLsqasq----ihnrIPCPLCRHITVLP 97  African clawed frog
XP_018086180  28 TECPICYSSYDNiFKTPLKLPCAHTFCMECLGRLclfir----hlqeFPCPLCRTVVVIP 83  African clawed frog
M0QZC1        62 VECLICVSSFDGvFKLPKRLDCGHVFCLECLARLslata---gggnaVACPVCRAPTRLA 118 human

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