RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins
RNF183 is an E3 ubiquitin-protein ligase that is upregulated during intestinal inflammation and is negatively regulated by miR-7. It promotes intestinal inflammation by increasing the ubiquitination and degradation of inhibitor of kappa B, thereby resulting in secondary activation of the Nuclear factor-kappaB (NF-kB) pathway. The interaction between RNF183-mediated ubiquitination and miRNA may be an important novel epigenetic mechanism in the pathogenesis of inflammatory bowel disease (IBD). The biological function of RNF223 remains unclear. Both RNF183 and RNF223 contain an N-terminal C3HC4-type RING-HC finger and a C-terminal transmembrane domain.