Conserved Protein Domain Family
RING-HC_RNF183_like

?
cd16556: RING-HC_RNF183_like 
RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins
RNF183 is an E3 ubiquitin-protein ligase that is upregulated during intestinal inflammation and is negatively regulated by miR-7. It promotes intestinal inflammation by increasing the ubiquitination and degradation of inhibitor of kappa B, thereby resulting in secondary activation of the Nuclear factor-kappaB (NF-kB) pathway. The interaction between RNF183-mediated ubiquitination and miRNA may be an important novel epigenetic mechanism in the pathogenesis of inflammatory bowel disease (IBD). The biological function of RNF223 remains unclear. Both RNF183 and RNF223 contain an N-terminal C3HC4-type RING-HC finger and a C-terminal transmembrane domain.
Statistics
?
PSSM-Id: 319470
View PSSM: cd16556
Aligned: 8 rows
Threshold Bit Score: 89.4533
Threshold Setting Gi: 591351720
Created: 5-Nov-2015
Updated: 18-Aug-2016
Structure
?
Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens transcription factor PML (1BOR) binds two Zn2+ ions through its RING-HC finger.
  • Citation:PMID 8317827
  • Citation:PMID 7729428

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
Feature 1         #  #               # #  #  #                   #  #    
gi 338819332  50 ECSICFSGYDniFKTPKELSCTHVFCLECLARLaaaqpvgrpggeaVPCPFCRQPT 105
gi 847148701 143 ECSICFTKYDniFKTPKLLQCSHTLCLECVARLvaalpp-ekqaedVLCPFCRQPT 197
gi 591351720  62 ECSICFNTYDnsFKTPKLLQCSHVFCLECVARLtsalpq-prvedqLPCPLCRQLT 116
gi 528518008  27 ECSICFNTYDnvFKTPKQLDCTHTFCLECLSRImttsmd--pqnskIPCPFCRQPT 80
gi 556972762  26 DCAICWSRYDntFRTPKQLECQHSFCLECLARMslaava-eqtagrLPCPLCRHPT 80
gi 632964399  11 ECVICWNRYDnaFRMPKVLECKHTFCLECLARMslafvs--esapeVSCPLCRQLT 64
gi 512856171 131 DCPVCFSKYDi-YRTPKELSCRHTFCIVCLKLLlhhek----dawlIPCPICRCST 181
gi 613504226  12 ECPVCWNPFNntFHTPKMLDCCHSFCVECLAHLslvtp----arrrLLCPLCRQPT 63

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap