Conserved Protein Domain Family
RING-HC_RNF207

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cd16558: RING-HC_RNF207 
RING finger, HC subclass, found in RING finger protein 207 (RNF207) and similar proteins
RNF207 is a cardiac-specific E3 ubiquitin-protein ligase that plays an important role in the regulation of cardiac repolarization. It regulates action potential duration, likely via effects on human ether-a-go-go-related gene (HERG) trafficking and localization in a heat shock protein-dependent manner. RNF207 contains a C3HC4-type RING-HC finger, Bbox 1 and Bbox C-terminal (BBC), as well as a C-terminal non-homologous region (CNHR).
Statistics
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PSSM-Id: 319472
View PSSM: cd16558
Aligned: 9 rows
Threshold Bit Score: 84.3706
Threshold Setting Gi: 118100972
Created: 20-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens transcription factor PML (1BOR) binds two Zn2+ ions through its RING-HC finger.
  • Citation:PMID 8317827
  • Citation:PMID 7729428

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
Feature 1            #  #           # #  #  #           #  # 
gi 158563957   22 PLVCPLCHVqYERPCLLDCFHDFCAGCLRGRAtDGRLTCPLCQ 64
gi 319803093   22 PLVCHLCQEqYEHPCLLDCYHTFCASCLRGRVaDSRLTCPVCG 64
gi 118100972   22 PLVCLLCHGpFQQPCLLDCYHAFCASCLRGRAaSGRLRCPLCG 64
gi 405970203   54 PLQCYLCNEkYNDPCILSCYHSYCSQCLRGRAtDNRLSCPLCG 96
gi 229296880   22 PMWCYLCNErFEEPCLLDCFHAFCAQCLRGRAsEGLISCPICS 64
gi 212514169   38 PLICYLCNDyYSNPCLLQCYHTFCLKCLRGREvEGRISCPVCG 80
gi 512854447   22 PLACFLCHEqYEHPCLLDCYHNFCASCLRGRAiDNRLTCPLCG 64
gi 632960215   22 PLVCHLCYQqYEHPCLLDCHHTFCANCLRGRAsDGRLSCPLCG 64
gi 919098970   33 PLLCYLCNEhYEDPCLLKCFHSFCAKCLRGRGaEGKMKCPLCG 75

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