Conserved Protein Domain Family
RING-HC_RNF208

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cd16559: RING-HC_RNF208 
RING finger, HC subclass, found in RING finger protein 208 (RNF208) and similar proteins
RNF208 is an E3 ubiquitin-protein ligase whose activity can be modulated by S-nitrosylation. It contains a C3HC4-type RING-HC finger.
Statistics
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PSSM-Id: 438221
Aligned: 8 rows
Threshold Bit Score: 73.814
Created: 18-May-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #  #               # #  #  #                                      #  #      
Q9H0X6        140 PLECPTCGHSYnvtqrrPRVLSCLHSVCEQCLQILYescp-----------------------kykFISCPTCRRETVL 195  human
AAI23251      115 PLECPTCGHMYnftnkrPRILSCLHSVCEECLQILYescp-----------------------kykFISCPTCKRETVL 170  African clawed...
EMP26425      145 PLECPTCGHMYnftnkrPRILSCLHSVCEECLQILYescp-----------------------kykFISCPTCKRETVL 200  green seaturtle
XP_006001475  126 PLECPTCGHMYnftnkrPRILSCLHSVCEECLQILYescp-----------------------kykFISCPTCKRETVL 181  coelacanth
XP_007898418  123 PLECPTCCHTYnftnkrPRILSCLHSVCEECLQILYescp-----------------------kykFISCPTCKRETVL 178  elephant shark
CDQ59170      123 PLDCPTCGHTYnftgkrPRILSCLHSVCEECLQILYescp-----------------------kykFISCPTCRRETVL 178  rainbow trout
XP_011410567   28 SLLCPRCNDSYt----dPRLLSCLHSFCTPCLQSLVdgka-----------------------skqTVTCPTCREITKL 79   Amphimedon que...
NP_001259377  158 DKLCKLCSLRLv----mPRILSCLHVFCEDCLQAVVskdtmsasspnscssssfdgsehqnrlsavFIECPVCKQETPL 232  fruit fly

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