Conserved Protein Domain Family
RING-HC_RNF208

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cd16559: RING-HC_RNF208 
RING finger, HC subclass, found in RING finger protein 208 (RNF208) and similar proteins
RNF208 is an E3 ubiquitin-protein ligase whose activity can be modulated by S-nitrosylation. It contains a C3HC4-type RING-HC finger.
Statistics
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PSSM-Id: 319473
View PSSM: cd16559
Aligned: 12 rows
Threshold Bit Score: 77.5185
Threshold Setting Gi: 442615656
Created: 18-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens transcription factor PML (1BOR) binds two Zn2+ ions through its RING-HC finger.
  • Citation:PMID 8317827
  • Citation:PMID 7729428

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
Feature 1            #  #                # #  #  #                                      #  #    
gi 239938696  140 PLECPTCGHSYnvt-qrrPRVLSCLHSVCEQCLQILyesc-----------------------pkykFISCPTCRRET 193
gi 114107888  115 PLECPTCGHMYnft-nkrPRILSCLHSVCEECLQILyesc-----------------------pkykFISCPTCKRET 168
gi 465955403  145 PLECPTCGHMYnft-nkrPRILSCLHSVCEECLQILyesc-----------------------pkykFISCPTCKRET 198
gi 556995308  126 PLECPTCGHMYnft-nkrPRILSCLHSVCEECLQILyesc-----------------------pkykFISCPTCKRET 179
gi 632964482  123 PLECPTCCHTYnft-nkrPRILSCLHSVCEECLQILyesc-----------------------pkykFISCPTCKRET 176
gi 642128869  123 PLDCPTCGHTYnft-gkrPRILSCLHSVCEECLQILyesc-----------------------pkykFISCPTCRRET 176
gi 761905108   28 SLLCPRCNDSYt-----dPRLLSCLHSFCTPCLQSLvdgk-----------------------askqTVTCPTCREIT 77
gi 442615656  158 DKLCKLCSLRLv-----mPRILSCLHVFCEDCLQAVvskdtmsasspnscssssfdgsehqnrlsavFIECPVCKQET 230
gi 919003274   34 EYLCTLCEEKFn-----qPRLLSCLHTFCLPCLEKLtkdpet--------------------dapleAITCPLCKQET 86
gi 443731537   28 STKCALCQETFt-----iPKVLACFHSFCQPCLEKLqsc--------------------------pdRIECPTCQADT 74
gi 405958381   33 NTRCSICQETYt-----iPKVLSCFHTFCQPCLEKLqev--------------------------adKISCPECHQDT 79
gi 669140104   17 SLECEICNLPYdntethtPRLLSCGHTFCQSCLGGWattash-------------------ghsgtnIITCPSCRRET 75

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