Conserved Protein Domain Family

cd16560: RING-HC_RNF212_like 
RING finger, HC subclass, found in RING finger proteins RNF212, RNF212B and similar proteins
The family includes RING finger protein RNF212, RNF212B, and their homologs. RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis. It plays a central role in designating crossover sites and coupling chromosome synapsis to the formation of crossover-specific recombination complexes. It also functions as an E3 ligase for small ubiquitin-related modifier (SUMO) modification. RNF212B shows high sequence similarity with RNF212, but its biological function remains unclear. Members in this family contain an N-terminal C3HC4-type RING-HC finger. The family also includes two homologs of RNF212, meiotic procrossover factors Zip3 and ZHP-3, which have been identified in Saccharomyces cerevisiae and Caenorhabditis elegans, respectively. Budding yeast Zip3 is a small ubiquitin-related modifier (SUMO) E3 ligase implicated in the SUMO pathway of post-translational modification. It sumoylates chromosome axis proteins, thus promoting synaptonemal complex polymerization. It also acts as a Smt3 E3 ligase. Zip3 includes a SUMO Interacting Motif (SIM) and a modified C3HCHC2-type RING-HC finger that are important for Zip3 in vitro E3 ligase activity and necessary for SC polymerization and correct sporulation. ZHP-3 acts at crossovers to couple meiotic recombination with synaptonemal complex disassembly and chiasma formation in Caenorhabditis elegans. It possess a C3HC4-type RING-HC finger.
PSSM-Id: 319474
View PSSM: cd16560
Aligned: 6 rows
Threshold Bit Score: 65.2091
Threshold Setting Gi: 205831118
Created: 24-Mar-2015
Updated: 18-Aug-2016
Aligned Rows:
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
  • Comment:Based on the structural evidence that Homo sapiens TFIIH MAT1 subunit (1G25) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
Feature 1         #  #                 # #  #  #           #  # 
gi 121943260   6 FCNRCFqpph---rtscFSLTNCGHVYCDACLGkgk---knECLICK 46
gi 205831118   5 HCNQCFrkd-----gahFFVTSCGHIFCKKCVTl------eKCAVCG 40
gi 392886432   5 HCNKCFnrkp----pdgFFISSCFHIFCTKCAKad----laVCLICK 43
gi 66825317    7 HCNSCWkeii---endrCIITSCSHIFCDLCASnklctddrLCPICD 50
gi 761912114  16 HCNHCYteppkdrrntqFIITSCGHLFCGKCYGkr----ekFCLVCK 58
gi 699244852   6 HCNACFvriih--gpvsFSVTNCAHIFCNKCIErva---nsTCTVCN 47

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