Conserved Protein Domain Family
RING-HC_RNF220

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cd16563: RING-HC_RNF220 
RING finger, HC subclass, found in RING finger protein 220 (RNF220) and similar proteins
RNF220 is an E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of Sin3B, a scaffold protein of the Sin3/HDAC (histone deacetylase) corepressor complex. It can also bind E2 and mediate auto-ubiquitination of itself. Moreover, RNF220 specifically interacts with beta-catenin, and enhances canonical Wnt signaling through ubiquitin-specific protease 7 (USP7)-mediated deubiquitination and stabilization of beta-catenin, which is independent of its E3 ligase activity. RNF220 contains a characteristic C3HC4-type RING-HC finger at its C-terminus.
Statistics
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PSSM-Id: 319477
View PSSM: cd16563
Aligned: 21 rows
Threshold Bit Score: 78.9891
Threshold Setting Gi: 391325511
Created: 18-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens HHARI (4KBL) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
Feature 1         #  #            # #  #  #          #  # 
gi 74756788  513 KCLICMdsYSMPLTSIQCWHVHCEECWLRTLGaKKLCPQCN 553
gi 443728156 371 RCLICMdsYKQPLVSVQCWHVYCEDCWLRTLGaKKLCPQCN 411
gi 443927028 279 VCRICLdpFMEPVVSTGCWHLFCRECWLRSLGsTKYCPICK 319
gi 241755530 169 KCLICMepYTVPVVSVCCWHVHCQDCWLKTLGaKKLCPQCN 209
gi 21355715  345 KCLICIddYKNPAISVSCWHVHCEQCWLQTLGaRKLCPQCN 385
gi 321461989 313 RCLICLgdYRQPVVSTSCWHVHCEECWLQALGnKKLCPQCN 353
gi 72005136  413 KCQICMgaYNTPLVSIQCWHVHCEDCWLKTLAsKKLCPQCQ 453
gi 60468045  700 SCLICMesYKTPLVSINCWHVNCEDCWLASLKeKKLCPQCN 740
gi 470363736 373 KCLICMepYTNPAVSINCWHVHCQQCWLATLGaKKVCPQCN 413
gi 699244818 599 RCQICMdsYEDPLASIECWHVHCRKCWLRALSvKKLCPQCS 639

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