Conserved Protein Domain Family
RING-HC_RNF222

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cd16564: RING-HC_RNF222 
RING finger, HC subclass, found in RING finger protein 222 (RNF222) and similar proteins
RNF222 is an uncharacterized C3HC4-type RING-HC finger-containing protein. It may function as an E3 ubiquitin-protein ligase.
Statistics
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PSSM-Id: 319478
View PSSM: cd16564
Aligned: 9 rows
Threshold Bit Score: 65.9668
Threshold Setting Gi: 75158839
Created: 3-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus RNF146 (4QPL) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
Feature 1         #  #               # #  #  #                   #  # 
gi 182705199  13 ECPVCYEkfrdlegasRTLSCGHVFCHDCLVKYLLstrvdgqvqrtlVCPICR 65
gi 449280515  31 ECPVCYEkfhpleamrRQLSCGHIFCHDCLVKCLLsakldgqvqssiICPICR 83
gi 71895965   15 ECPVCYEqlqt-ntaeRRLNCGHSFCHDCLVKYLLsakqegsvrkniICPLCR 66
gi 557017668  14 ECPVCYEkladlgssrRALSCGHTFCHDCLVKTLVtanengpakkhiICPICR 66
gi 632943683   8 ECPVCYEkvsrhsaalRTLTCRHIFCHDCLVKTVVnqgtk---pkrvVCPVCR 57
gi 808879823  14 ECPVCYEsls---gteRTLSCGHVFCHDCLVKTLVsinsdgnirdtiVCPICR 63
gi 780168271  15 ECPLCLElyq----naRSLLCLHTFCHSCLVKYQDqqrv----knvlVCPTCR 59
gi 212287933  10 SCPVCLDffs----csISLSCTHVFCFDCIQRYILenhd-----fraMCPLCR 53
gi 75158839   15 KCPICLSlyn----saVSLSCNHVFCNACIVKSMKmd---------aTCPVCK 54

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