Conserved Protein Domain Family
RING-HC_RNF224_like

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cd16565: RING-HC_RNF224_like 
RING finger, HC subclass, found in RING finger protein RNF224, RNF225 and similar proteins
Both RNF224 and RNF225 are uncharacterized C3HC4-type RING-HC finger-containing proteins. They may function as an E3 ubiquitin-protein ligase.
Statistics
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PSSM-Id: 319479
View PSSM: cd16565
Aligned: 8 rows
Threshold Bit Score: 71.419
Threshold Setting Gi: 405951660
Created: 17-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens transcription factor PML (1BOR) binds two Zn2+ ions through its RING-HC finger.
  • Citation:PMID 8317827
  • Citation:PMID 7729428

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
Feature 1         #  #               # #  #  #                   #  # 
gi 342179218  23 DCIICCSAYDlsghlPRRLYCGHTFCQACVRRLdtpa----peqrWIPCPQCR 71
gi 301627586  41 DCIICFSSYNlthrlPRRLYCGHTFCQACLRRLdtlt----neqrWIPCPQCR 89
gi 118099144  32 ECIICYSSYDlcgrlPRRLYCGHTFCQACLKRLdava----neqrWIPCPQCR 80
gi 632964751  41 ECIICYSAHNlsdrlPRKLYCGHTFCQACLKRLemvl----neqkWIPCPQCR 89
gi 47216988   36 VCIVCFGSYDlatrlPRRLHCGHAFCQACLKRLdtvi----ndqvWIPCPQCR 84
gi 728048664  63 ECLICVSSFDgvfklPKRLDCGHVFCLECLARLslata---gggnAVACPVCR 112
gi 74997369    6 NCPNCLKVFNn----PRQLECDHILCTRCIEGVynpg-----rtpIIKCPVCD 49
gi 405951660  24 TCPLCLRHYSd----PKQLDCLHNFCEGCLNTYitskekkdlldgKFTCPICH 72

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