Conserved Protein Domain Family
RING-HC_RNF224
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cd16565: RING-HC_RNF224 
RING finger, HC subclass, found in RING finger protein RNF224 and similar proteins
RNF224 is uncharacterized C3HC4-type RING-HC finger-containing proteins. It may function as an E3 ubiquitin-protein ligase.
Links
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Statistics
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PSSM-Id: 438227
Aligned: 6 rows
Threshold Bit Score: 107.216
Created: 17-May-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #               # #  #  #               #  #          
P0DH78        22 TDCIICCSAYDLsgHLPRRLYCGHTFCQACVRRLDtpaPEQRWIPCPQCRQSTPTPRGG 80  human
XP_007898549  40 IECIICYSAHNLsdRLPRKLYCGHTFCQACLKRLEmvlNEQKWIPCPQCRQSTPCPRGG 98  elephant shark
CAG04930      35 LVCIVCFGSYDLatRLPRRLHCGHAFCQACLKRLDtviNDQVWIPCPQCRQNTPRPKGG 93  spotted green pufferfish
XP_018087989  31 MDCIICFSSYNLthRLPRRLYCGHTFCQTCLRRLDtltNEQRWIPCPQCRQNTPTPRGG 89  African clawed frog
NP_001313518  54 LDCIVCYSAYNLgeRLPRKLYCGHTFCQACLKRLDtliNEQMWIPCPQCRQNTPVPRGG 112 zebrafish
OPJ86378     136 VECIICYSSYDLcsRLPRRLYCGHTFCQACLKRLDavaNEQRWIPCPQCRQNTPTPRGG 194 Patagioenas fasciata monilis

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