Conserved Protein Domain Family

cd16568: RING-HC_ScPSH1_like 
RING finger, HC subclass, found in Saccharomyces cerevisiae POB3/SPT16 histone-associated protein 1 (ScPSH1), Arabidopsis thaliana Protein KEEP ON GOING (AtKEG) and similar proteins
ScPSH1 is a Cse4-specific E3 ubiquitin ligase that interacts with the kinetochore protein Pat1 and targets the degradation of budding yeast centromeric histone H3 variant, CENP-ACse4, which is essential for faithful chromosome segregation. ScPSH1 contains a C3HC4-type RING-HC finger and a DNA directed RNA polymerase domain. AtKEG is an E3 ubiquitin ligase essential for Arabidopsis growth and development. It maintains low levels of ABSCISIC ACID-INSENSITIVE5 (ABI5) in the absence of stress and thus functions as a negative regulator of abscisic acid (ABA) signaling. AtKEG is a multidomain protein that includes a C3HC4-type RING-HC finger, a kinase domain, ankyrin repeats, and 12 HERC2-like (for HECT and RCC1-like) repeats.
PSSM-Id: 319482
View PSSM: cd16568
Aligned: 4 rows
Threshold Bit Score: 73.3034
Threshold Setting Gi: 633906543
Created: 26-Apr-2016
Updated: 18-Aug-2016
Aligned Rows:
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
  • Comment:Based on the structural evidence that Homo sapiens TRAF2 (3KNV) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50
Feature 1          #  #               # #  #  #                     #  # 
gi 74676541    29 VCSICHDYMfv----pMMTPCGHNYCYGCLNTWfasn-------tqkeLACPQCR 72
gi 633906543  179 VCPICHDPLrl---efAMLSCGHATCTKCLVRLeevsr-----srrrrLQCPTCR 225
gi 300169872  997 ICPVCHDALes---gaMVLPCGHLLCGKCLNLIvnrqkapangadfkrIACPTCR 1048
gi 218526495    9 CCSVCHTRYnedervpLLLQCGHGFCKDCLSKMfsts-------sdttLTCPRCR 56

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