Conserved Protein Domain Family
RING-HC_SIAHs

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cd16571: RING-HC_SIAHs 
RING finger, HC subclass, found in Drosophila melanogaster protein Seven-in-Absentia (sina) and its homologs
The family includes the Drosophila melanogaster protein Seven-in-Absentia (sina), its mammalian orthologs, SIAH1 and SIAH2, plant SINA-related proteins, and similar proteins. The Drosophila homolog sina plays an important role in the phyllopod-dependent degradation of the transcriptional repressor tramtrack as for the formation of the R7 photoreceptor in the developing eye of Drosophila melanogaster. Both of SIAH1 and SIAH2 are E3 ubiquitin-protein ligases, mediating the ubiquitinylation and subsequent proteasomal degradation of biologically important target proteins that regulate general functions, such as cell cycle control, apoptosis, and DNA repair. They are inducible by the tumor suppressor and transcription factor p53. SIAH2 can also be regulated by sex hormones and cytokine signaling. Moreover, they share high sequence similarity, but possess contrary roles in cancer, with Siah1 more often acting as a tumor suppressor while Siah2 functions as a proto-oncogene. Plant SINAT1-5 are putative E3 ubiquitin ligase involved in the regulation of stress responses. All family members possess two characteristic domains, an N-terminal C3HC4-type RING-HC finger and a C-terminal tumor necrosis factor (TNF) receptor associated factor (TRAF)-like substrate-binding domain (SBD).
Statistics
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PSSM-Id: 319485
View PSSM: cd16571
Aligned: 19 rows
Threshold Bit Score: 50.7462
Threshold Setting Gi: 300167357
Created: 24-Jul-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens Parkin (5C1Z) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
Feature 1          #  #          #   #  #  #          #  # 
gi 46577493   39 FECPVCFDYvlPPILQCQSGHLVCSNCRPKLt----CCPTCR 76
gi 46577512   44 LECPVCTNSmyPPIHQCHNGHTLCSTCKSRVh---nRCPTCR 82
gi 313224802  85 FECPVCYDYvlPPIHQCSIGHLICGQCRPKLq----SCPTCR 122
gi 195996331  49 FECPVCYDYvlPPIKQCTRGHLICEKCRLKIl----KCPVCN 86
gi 321469580 236 IECPVCLEPicPPVHQCRRGHLVCGKCKSQLh----QCPTCR 273
gi 46577513  104 LECPVCFGYimPPIMQCPRGHLICSTCRSKLt----ICPVCR 141
gi 300167357   3 LDCSVCMESltPPIFQCSNGHIACQSCRSKIs---dVCPTCS 41
gi 294463085  65 FECSICMEPlsPPIFQCSNGHIACSSCCVMMd---nRCPSCL 103
gi 557123546 276 LECGVCMERmqPPIYQCKEGHTLCCSCQQRLn----SCPTCR 313
gi 428171257  29 LDCTVCFDSiaGPVFQCTEGHLLCQTCWSRLntpdaGCPTCS 70

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