Conserved Protein Domain Family
RING-HC_SpRad8-like
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cd16572: RING-HC_SpRad8-like 
RING finger, HC subclass, found in Schizosaccharomyces pombe DNA repair protein Rad8 (SpRad8) and similar proteins
SpRad8 is a conserved protein homologous to Saccharomyces cerevisiae DNA repair protein Rad5 and human helicase-like transcription factor (HLTF) that is required for error-free postreplication repair by contributing to polyubiquitylation of PCNA. SpRad8 contains a C3HC4-type RING-HC finger responsible for the E3 ubiquitin ligase activity, a SNF2-family helicase domain including an ATP binding site, and a family-specific HIRAN domain (HIP116, Rad5p N-terminal domain) that contributes to nuclear localization.
Links
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Statistics
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PSSM-Id: 438234
Aligned: 6 rows
Threshold Bit Score: 111.446
Created: 18-Apr-2016
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #  #              # #  #  #                 #  #          
P36607        871 EALITECPICCNEpi--qNPLLLNCKHACCGDCLSEHIQYQKRRNiipPLCHTCRQPFNEQDVY 932  Schizosaccharomyces pombe 972h-
KTW27423      759 EKAQNECSICSASpi--vEEAITPCWHIACKSCIKKHIEFQKSHNk-kPLCHMCRSPIDEQNIY 819  Pneumocystis carinii B80
Q7S1P9        961 DEAVNECPICAEEpm--iDQAVTGCWHSACKKCLLDYIKHQTDRNe-vPRCFQCREHINIRDIF 1021 Neurospora crassa OR74A
Q6C2R8        776 QSAPPECPICAEDv---tKLAISKCLHMGCVDCLADNVRFQESKKq-tPVCCICRQPAALKDIF 835  Yarrowia lipolytica CLIB122
Q4PGG5       1102 SDGENECPICLEEsq-isPCYLPRCMHSACKACLVDYLGQCKQKGd-qGACPTCRKGPVQETDL 1163 Ustilago maydis 521
XP_018737506  938 DGTEKECPICTTEpipndELAVTECWHVACLACILKHIEFQKKKNe-vPRCPTCRATINAKRLF 1000 Sugiyamaella lignohabitans

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