Conserved Protein Domain Family
RING-HC_SpRad8_like

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cd16572: RING-HC_SpRad8_like 
RING finger, HC subclass, found in Schizosaccharomyces pombe DNA repair protein Rad8 (SpRad8) and similar proteins
SpRad8 is a conserved protein homologous to Saccharomyces cerevisiae DNA repair protein Rad5 and human helicase-like transcription factor (HLTF) that is required for error-free postreplication repair by contributing to polyubiquitylation of PCNA. SpRad8 contains a C3HC4-type RING-HC finger responsible for the E3 ubiquitin ligase activity, a SNF2-family helicase domain including an ATP binding site, and a family-specific HIRAN domain (HIP116, Rad5p N-terminal domain) that contributes to nuclear localization.
Statistics
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PSSM-Id: 319486
View PSSM: cd16572
Aligned: 5 rows
Threshold Bit Score: 66.8418
Threshold Setting Gi: 284085783
Created: 18-Apr-2016
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens HHARI (4KBL) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
Feature 1            #  #            # #  #  #                 #  # 
gi 548669     874 ITECPICCnepiqnPLLLNCKHACCGDCLSEHIqyqkrrniippLCHTCR 923
gi 403359298  817 IMQCLSCLthi-erPLMLSCGHSLCRDCVTKHLhpfkk--dsmvLCEKCT 863
gi 284085783 1464 PEDCPICYgpk-enPVLLSCGHSLCRDCFICQLdqm------tfNCCECD 1506
gi 968582731  762 QNECSICSaspiveEAITPCWHIACKSCIKKHIefqks-hnkkpLCHMCR 810
gi 597439625  964 VNECPICAeepmidQAVTGCWHSACKKCLLDYIkhqtd-rnevpRCFQCR 1012

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