Conserved Protein Domain Family
RING-HC_TRIM42_C-III

?
cd16578: RING-HC_TRIM42_C-III 
RING finger, HC subclass, found in tripartite motif-containing protein 42 (TRIM42) and similar proteins
TRIM42 belongs to the C-III subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil domain. It also has a novel cysteine-rich motif N-terminal to the RBCC domain, as well as a COS (carboxyl-terminal subgroup one signature) box and a fibronectin type-III (FN3) domain positioned C-terminal to the RBCC domain. TRIM42 can interact with TRIM27, a known cancer-associated protein. Its precise biological function remains unclear.
Statistics
?
PSSM-Id: 319492
View PSSM: cd16578
Aligned: 5 rows
Threshold Bit Score: 67.6312
Threshold Setting Gi: 196014697
Created: 30-Mar-2015
Updated: 18-Aug-2016
Structure
?
Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus Hakai (3VK6) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #  #           # #  #  #                                               #  #  
gi 296452851 143 HLNCPMCSRLRLHSFMLPCNHSLCEKCLRQLqkhaev-----------------------------tenffiLICPVCDR 193
gi 591375732  40 QLICPLCKQLYLYPFMLPCNHCICEKCISKSkaqaev-----------------------------tenffiIVCPVCVK 90
gi 334329626 142 HLVCPLCKKLRMHSYILPCQHCICQVCLKKVqeaaei-----------------------------teiftiIACPVCHS 192
gi 196014697   4 YLTCPLCQYYFNHPVILPCGHSVCLKCGQRVqksiataspglrakraslpslhygdggqvtrsksvdlmvtsIVCPVCVK 83
gi 326430762  50 EHVCFLCMGLLIPPVVLPCTHRVCEECFRRIeel------------------------------------snMECPMCRR 93

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap