Conserved Protein Domain Family
RING-HC_TRIM42_C-III
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cd16578: RING-HC_TRIM42_C-III 
RING finger, HC subclass, found in tripartite motif-containing protein 42 (TRIM42) and similar proteins
TRIM42 belongs to the C-III subclass of the TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil domain. It also has a novel cysteine-rich motif N-terminal to the RBCC domain, as well as a COS (carboxyl-terminal subgroup one signature) box and a fibronectin type-III (FN3) domain positioned C-terminal to the RBCC domain. TRIM42 can interact with TRIM27, a known cancer-associated protein. Its precise biological function remains unclear.
Links
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Statistics
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PSSM-Id: 438240
Aligned: 5 rows
Threshold Bit Score: 99.4626
Created: 30-Mar-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #  #           # #  #  #                  #  #     
Q8IWZ5       139 HLVNHLNCPMCSRLRLHSFMLPCNHSLCEKCLRQLQKHAEVTEnFFILICPVCDRSHC 196 human
XP_003341245 138 NLVNHLVCPLCKKLRMHSYILPCQHCICQVCLKKVQEAAEITEiFTIIACPVCHSTHC 195 gray short-tailed opossum
XP_004663669 139 YLVDHLTCPQCRRLRLHSFMLPCNHSLCEKCLRHLQKHAEVTEnFFMLVCPVCSRSHC 196 lesser Egyptian jerboa
XP_007518908 140 QLLEHLSCPLCHRLRLHSFMLPCHHSLCEKCLRRLQKQAEVTEnFFILVCPVCDRAHC 197 western European hedgehog
XP_004602994 141 QLVAHLLCPLCNRLRLHSFMLPCHHSLCGKCLRQLQKKAEVTEnFFILVCPVCNRSHC 198 European shrew

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