1BOR


Conserved Protein Domain Family
RING-HC_PML_C-V

?
cd16579: RING-HC_PML_C-V 
Click on image for an interactive view with Cn3D
RING finger, HC subclass, found in promyelocytic leukemia protein (PML) and similar proteins
Protein PML, also known as RING finger protein 71 (RNF71) or tripartite motif-containing protein 19 (TRIM19), is predominantly a nuclear protein with a broad intrinsic antiviral activity. It is the eponymous component of PML nuclear bodies (PML NBs) and has been implicated in a wide variety of cell processes, including DNA damage signaling, apoptosis, and transcription. PML interferes with the replication of many unrelated viruses, including human immunodeficiency virus 1 (HIV-1), human foamy virus (HFV), poliovirus, influenza virus, rabies virus, EMCV, adeno-associated virus (AAV), and vesicular stomatitis virus (VSV). It also selectively interacts with misfolded proteins through distinct substrate recognition sites and conjugates these proteins with the small ubiquitin-like modifiers (SUMOs) through its SUMO ligase activity. PML belongs to the C-V subclass of TRIM (tripartite motif) family of proteins that are defined by an N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, as well as an uncharacterized region positioned C-terminal to the RBCC domain.
Statistics
?
PSSM-Id: 319493
View PSSM: cd16579
Aligned: 3 rows
Threshold Bit Score: 30.4123
Threshold Setting Gi: 157830418
Created: 21-Mar-2015
Updated: 18-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
 
Zn binding siteRING-HC finger
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30
                 ....*....|....*....|....*....|....*....
Feature 1         #  #           # #  #  #         #  # 
1BOR_A         8 RCQQCQaeAKCPKLLPCLHTLCSGCLEas--gmQCPICQ 44
gi 215274219  56 RCQQCQaeAKCPKLLPCLHTLCSGCLEas--gmQCPICQ 92
gi 513200871  19 LCEGCRqeSPDLKLLTCLHTLCLGCLRenkpvgQCPVCQ 57

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap