Conserved Protein Domain Family
RING-HC_TRIM13_like_C-V

?
cd16581: RING-HC_TRIM13_like_C-V 
RING finger, HC subclass, found in tripartite motif-containing proteins TRIM13, TRIM59 and similar proteins
TRIM13 and TRIM59, two closely related tripartite motif-containing proteins, belong to the C-V subclass of TRIM (tripartite motif) family of proteins that are defined by an N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, followed by a C-terminal transmembrane domain. TRIM13, also known as B-cell chronic lymphocytic leukemia tumor suppressor Leu5, leukemia-associated protein 5, putative tumor suppressor RFP2, RING finger protein 77 (RNF77), or Ret finger protein 2, is an endoplasmic reticulum (ER) membrane anchored E3 ubiquitin-protein ligase that interacts proteins localized to the ER, including valosin-containing protein (VCP), a protein indispensable for ER-associated degradation (ERAD). TRIM59, also known as RING finger protein 104 (RNF104) or tumor suppressor TSBF-1, is a putative E3 ubiquitin-protein ligase that functions as a novel multiple cancer biomarker for immunohistochemical detection of early tumorigenesis.
Statistics
?
PSSM-Id: 319495
View PSSM: cd16581
Aligned: 6 rows
Threshold Bit Score: 84.4291
Threshold Setting Gi: 190582951
Created: 8-May-2013
Updated: 18-Aug-2016
Structure
?
Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens transcription factor PML (1BOR) binds two Zn2+ ions through its RING-HC finger.
  • Citation:PMID 8317827
  • Citation:PMID 7729428

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
Feature 1            #  #           # #  #  #                      #  # 
gi 71153168    6 EDLTCPICCSlFDDPRVLPCSHNFCKKCLEGILegsvrns--lwrpapFKCPTCR 58
gi 74714421    6 EELTCPICYSiFEDPRVLPCSHTFCRNCLENILqasgnfyiwrplripLKCPNCR 60
gi 291242614  10 GQLSCPLCLDrFNDPKVLPCLHSFCRRCLDDRAaep----------diLRCPTCH 54
gi 260811452  14 LFLTCSICMRhFQDPRVLPCLHTFCRECLQERAakq----------qpLECPTCR 58
gi 761914695  20 EMLECSVCLDkYKDPRILPCHHAFCKTCIDGLTvqe----------nsLKCPSCR 64
gi 190582951   6 HKLTCSSCGNiFNEPKILPCLHTFCKNCIEAFMae-----------gsAFCPVCN 49

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap