Conserved Protein Domain Family
RING-HC_TRIM40-C-V

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cd16583: RING-HC_TRIM40-C-V 
RING finger, HC subclass, found in tripartite motif-containing protein 40 (TRIM40) and similar proteins
TRIM40, also known as probable E3 NEDD8-protein ligase or RING finger protein 35 (RNF35), is highly expressed in the gastrointestinal tract including the stomach, small intestine, and large intestine. It enhances neddylation of inhibitor of nuclear factor kappaB kinase subunit gamma (IKKgamma), inhibits the activity of nuclear factor-kappaB (NF-kappaB)-mediated transcription, and thus prevents inflammation-associated carcinogenesis in the gastrointestinal tract. TRIM40 belongs to the C-V subclass of TRIM (tripartite motif) family of proteins that are defined by an N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region , as well as an uncharacterized region positioned C-terminal to the RBCC domain.
Statistics
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PSSM-Id: 319497
View PSSM: cd16583
Aligned: 8 rows
Threshold Bit Score: 71.85
Threshold Setting Gi: 21357313
Created: 14-Apr-2016
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Rattus norvegicus RNF4 (4AP4) binds four Zn2+ ions through its two RING-HC fingers.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
Feature 1         #  #             # #  #  #                #  #  
gi 229463021  13 VCPICQEslk--eaVSTNCGHLFCRVCLTQHVekasa-sgvfCCPLCRK 58
gi 21357313  265 KCPICMDsvskrepVSTKCGHVFCRECIETAIra------thKCPICNK 307
gi 123440136 102 TCPICMEelh--dpVATPCGHVFCRRCIEEWLir------seCCPNCNA 142
gi 97203000   13 VCPICQEslk--eaVSTNCGHLFCRVCLTQHVekasa-sgvfCCPLCRK 58
gi 56404682   11 ICPICLDplk--eaVSTDCRHLFCRMCLIRHMdkasv-sgvlSCPVCRK 56
gi 123788639  11 ICPICLDplk--eaVSTDCRHLFCRMCLTQHMdkasv-sgilSCPVCRK 56
gi 551626480 262 TCPICLEpid-shpVATTCLHVFCRGCIAGWLeqa----deaTCPMCRE 305
gi 693497703 141 TCPICLDeap-tapQTTTCGHAFCFGCIARHAlttresgkpsKCPVCAV 188

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