Conserved Protein Domain Family

cd16584: RING-HC_TRIM56_C-V 
RING finger, HC subclass, found in tripartite motif-containing protein 56 (TRIM56) and similar proteins
TRIM56, also known as RING finger protein 109 (RNF109), is a virus-inducible E3 ubiquitin ligase that restricts pestivirus infection. It positively regulates the Toll-like receptor 3 (TLR3) antiviral signaling pathway, and possesses antiviral activity against bovine viral diarrhea virus (BVDV), a ruminant pestivirus classified within the family Flaviviridae shared by tick-borne encephalitis virus (TBEV). It also possesses antiviral activity against two classical flaviviruses, yellow fever virus (YFV) and dengue virus (DENV), as well as a human coronavirus, HCoV-OC43, which is responsible for a significant share of common cold cases. It may do not act on positive-strand RNA viruses indiscriminately. Moreover, TRIM56 is an interferon-inducible E3 ubiquitin ligase that modulates STING to confer double-stranded DNA-mediated innate immune responses. TRIM56 belongs to the C-V subclass of TRIM (tripartite motif) family of proteins that are defined by an N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, as well as an uncharacterized region positioned C-terminal to the RBCC domain.
PSSM-Id: 319498
View PSSM: cd16584
Aligned: 9 rows
Threshold Bit Score: 73.9655
Threshold Setting Gi: 443700444
Created: 31-Jul-2013
Updated: 18-Aug-2016
Aligned Rows:
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
  • Comment:Based on the structural evidence that Mus musculus RNF146 (4QPL) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
Feature 1          #  #               # #  #  #                        #  # 
gi 56749788   19 LACKICLEQLr----aPKTLPCLHTYCQDCLAQLadg-------------grVRCPECR 60
gi 443700444  19 LQCKICLDGLk----vPKTLPCLHTFCADCVAYYidhnr--------ldsrkFSCPICR 65
gi 260822789  18 LSCGICFEPFt----kPKALPCQHSFCLRCLESQhkqwlqdcrrtshrqqqpFRCSTCR 72
gi 632982189  16 LNCKLCFEKYy----nPKALPCLHTYCEECLRKLvphk-----------tkvFQCPECR 59
gi 405970969  14 FNCTICLQQIv----kPRSLPCSHTFCEECLQHFisreaig----reessfeFKCPICR 64
gi 193083077  43 LTCQICFETYt----rPKSLNCQHTFCLKCLEEYtppn-----------svrVICPTCR 86
gi 954188751   7 IECPMCYDHYdeeqkiPRNLTCGHTYCEYCLEQIyel------------krrIECPSCR 53
gi 761908898  22 LTCPVCLDHYt----nPKSLPCLHSFCQDCLERLpldkk--------netyyLSCPACY 68
gi 390366897  17 LSCPICYEHYg----iPKALPCLHTFCSRCLQQIadg------------ymtITCPICS 59

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