Conserved Protein Domain Family

cd16585: RING-HC_TIF1_C-VI 
RING finger, HC subclass, found in the transcriptional inknown asiary factor 1 (TIF1) family and similar proteins
This family corresponds to the TIF1 family of transcriptional cofactors including TIF1alpha (TRIM24), TIF1beta (TRIM28), and TIF1gamma (TRIM33), which belongs to the C-VI subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, as well as a plant homeodomain (PHD), and a bromodomain (Bromo) positioned C-terminal to the RBCC domain. TIF1 proteins couple chromatin modifications to transcriptional regulation, signaling, and tumor suppression. They exert a deacetylase-dependent silencing effect when tethered to a promoter region. TIF1alpha and TIF1beta can homodimerize and contain a PXVXL motif necessary and sufficient for heterochromatin protein 1(HP1) binding. They bind nuclear receptors and Kruppel-associated boxes (KRAB) specifically and respectively. TIF1gamma is structurally closely related to TIF1alpha and TIF1beta, but has very little functional features in common with them. It does not interact with the KRAB silencing domain of KOX1 or the heterochromatinic proteins HP1alpha, beta and gamma. It cannot bind to nuclear receptors (NRs). TIF1delta (TRIM66) doesn"t have RING-HC finger and is not included here.
PSSM-Id: 319499
View PSSM: cd16585
Aligned: 6 rows
Threshold Bit Score: 78.6945
Threshold Setting Gi: 3183179
Created: 26-Mar-2015
Updated: 18-Aug-2016
Aligned Rows:
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
  • Comment:Based on the structural evidence that Homo sapiens transcription factor PML (1BOR) binds two Zn2+ ions through its RING-HC finger.
  • Citation:PMID 8317827
  • Citation:PMID 7729428

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
Feature 1            #  #                # #  #  #                                             #  
gi 12746552    53 LDTCAVCHQNIqs---rAPKLLPCLHSFCQRCLPApqrylmlpapmlgsaetpppvpapgspvsgsspfatqvgVIRCPV 129
gi 3183179     62 LEHCGVCRERLrp--erEPRLLPCLHSACSACLGPaapaaanssg--------------------dggaagdgtVVDCPV 119
gi 50235054    48 MDVCPVCKLSFss---rEPKLLPCLHSFCKRCLPAhsspagtt------------------------stakqlsMIRCPV 100
gi 768354051   25 LRNCLVCKWDLrk---rEPRMLPCLHSFCKDCLPDliqgyscip---------------------teyevlyegILSCPV 80
gi 313104270  122 LDTCAVCQQSLqsrreaEPKLLPCLHSFCLRCLPEperqlsvpipg------------------gsngdiqqvgVIRCPV 183
gi 229293915   13 LLQCGICKKDFn-----RPKLLPCLHSFCENCLVKhldespshg----------------------eeyeevpaSLKCPI 65

Feature 1         #    
gi 12746552   130 CSQEC 134
gi 3183179    120 CKQQC 124
gi 50235054   101 CQQEC 105
gi 768354051   81 CKQTC 85
gi 313104270  184 CRQEC 188
gi 229293915   66 CTTVV 70

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