Conserved Protein Domain Family
RING-HC_TRIM2_like_C-VII

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cd16586: RING-HC_TRIM2_like_C-VII 
RING finger, HC subclass, found in tripartite motif-containing protein TRIM2, TRIM3, and similar proteins
TRIM2, also known as RING finger protein 86 (RNF86), is an E3 ubiquitin-protein ligase that ubiquitinates the neurofilament light chain, a component of the intermediate filament in axons. Loss of function of TRIM2 results in early-onset axonal neuropathy. TRIM3, also known as brain-expressed RING finger protein (BERP), RING finger protein 97 (RNF97), or RING finger protein 22 (RNF22), is an E3 ubiquitin-protein ligase involved in the pathogenesis of various cancers. It also plays an important role in the central nervous system (CNS). In addition, TRIM3 may be involved in vesicular trafficking via its association with the cytoskeleton-associated-recycling or transport (CART) complex that is necessary for efficient transferrin receptor recycling, but not for epidermal growth factor receptor (EGFR) degradation. Both TRIM2 and TRIM3 belong to the C-VII subclass of TRIM (tripartite motif)-NHL family that is defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil domain, as well as a NHL (named after proteins NCL-1, HT2A and Lin-41 that contain repeats folded into a six-bladed beta propeller) repeat domain positioned C-terminal to the RBCC domain.
Statistics
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PSSM-Id: 319500
View PSSM: cd16586
Aligned: 9 rows
Threshold Bit Score: 90.9379
Threshold Setting Gi: 60459910
Created: 28-Jul-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens transcription factor PML (1BOR) binds two Zn2+ ions through its RING-HC finger.
  • Citation:PMID 8317827
  • Citation:PMID 7729428

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
Feature 1           #  #           # #  #  #             #  # 
gi 21363034   20 FLICSICLERYknPKVLPCLHTFCERCLQNYIPAHSltLSCPVCR 64
gi 390365340  38 FLVCGICLDRYkvPKVLPCLHTFCQNCLENYVPSESltLTCPLCR 82
gi 215273906  19 FLVCSICLDRYqcPKVLPCLHTFCERCLQNYIPAQSltLSCPVCR 63
gi 675363831  16 FLKCGVCLDRYenPKVLPCLHTFCERCLVTSMPAESltLSCPLCR 60
gi 229283564  15 FLICGICLERYktPKVLPCLHTFCECCLQTYIPQESlsLSCPVCR 59
gi 443708151  15 FLSCAICLERYsrPKVLPCLHTFCEQCLQEYIPPQSlsVACPICR 59
gi 60459910   20 LLSCAICDQRYkdPKVLPCLHTFCELCLSNVIPSESlsVTCPVCR 64
gi 291230141  18 FLKCGICLERYrtPKVLPCLHTFCQKCLQNYIPPHSlsLSCPICR 62
gi 918997487  72 FLSCGICLQQYtnPKVLPCLHTFCELCLYDYIPLESlsVSCPLCR 116

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