Conserved Protein Domain Family
RING-HC_RNF39
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cd16592: RING-HC_RNF39 
RING finger, HC subclass, found in RING finger protein 39 (RNF39) and similar proteins
RNF39, also called protein HZFw, may play a role in prolonged long term-potentiation (LTP) maintenance. It is involved in the etiology of Behcet's disease (BD). It may also be involved in HIV-1 replication. RNF39 acts as an E3 ubiquitin ligase that inhibits retinoic acid-inducible gene-I (RIG-I)-like receptor (RLR) pathways by mediating K48-linked ubiquitination and proteasomal degradation of DDX3X (DEAD-box RNA helicase 3, X-linked). RNF39 contains a typical C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438254
Aligned: 6 rows
Threshold Bit Score: 93.6686
Created: 30-Mar-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #  #           # #  #  #                     #  #     
Q9H2S5        82 LEQLATCPLCGGSFEDPVLLACEHSFCRACLARRWGtppatg--teasptACPCCGLPCP 139 human
XP_003770416  29 LEQLSTCPLCRGPFQDPVILACEHSFCRACLARRWDippgsgdsntappiICPCCGLSCP 88  Tasmanian devil
ETE61908      10 LQRAAICPACRGHFKDPVILDCDHSYCRACITRYWDeeaikg--nsprvvSCPQCKKVFE 67  king cobra
XP_029441053  10 LQDETLCPACSRYFDDPVTLECDHSYCRACIARHWRqeatavpagpgagfSCPCCGRAFE 69  two-lined caecilian
XP_020670974  10 LCEETTCPICLGYFQDPVMTDCGHVFCQKCIAQHWGvggep----gsdaiFCPQCREPCP 65  central bearded dragon
EMP28589      10 LLEEVVCPICLGYFKDPVSIDCEHNFCRVCITEHYEqrkme-----tegvFCPQCRENIK 64  Green sea turtle

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