Conserved Protein Domain Family
RING-HC_TRIM26_C-IV

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cd16598: RING-HC_TRIM26_C-IV 
RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
TRIM26, also known as acid finger protein (AFP), RING finger protein 95 (RNF95), or zinc finger protein 173 (ZNF173), is an E3 ubiquitin-protein ligase that negatively regulates interferon-beta production and antiviral response through polyubiquitination and degradation of nuclear transcription factor IRF3. It functions as an important regulator for RNA virus-triggered innate immune response by bridging TBK1 to NEMO (NF-kappaB essential modulator, also known as IKKgamma) and mediating TBK1 activation. It also acts as a novel tumor suppressor of hepatocellular carcinoma by regulating cancer cell proliferation, colony forming ability, migration, and invasion. TRIM26 belongs the C-IV subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, a B-box, and two coiled coil domains, as well as a B30.2/SPRY (SplA and ryanodine receptor) domain positioned C-terminal to the RBCC domain.
Statistics
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PSSM-Id: 319512
View PSSM: cd16598
Aligned: 6 rows
Threshold Bit Score: 73.7662
Threshold Setting Gi: 465956414
Created: 18-Apr-2016
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens TRIM34 (2EGP) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
Feature 1           #  #           # #  #  #                 #  # 
gi 17380344   13 EVTCSICLDYLRDPVTIDCGHVFCRSCTTDVRPisg----srPVCPLCK 57
gi 38503306   13 EVTCSICLDYLRDPVTIDCGHVFCRSCTTDVRPisg----srPVCPLCK 57
gi 50401217   13 EVTCSICLDYLRDPVTIDCGHVFCRSCTTDIHPvsg----grPVCPLCK 57
gi 50401219   13 EVTCSICLDYLRDPVTIDCGHVFCRSCTSDIRPisg----nrPVCPLCK 57
gi 342187125  13 EVTCSICLDYLRDPVTIDCGHVFCRSCTSDIRPisg----nrPVCPLCK 57
gi 465956414  14 EVSCSICLEYLRDPVTIDCGHNFCCVCITDYCErwegsttevFFCPQCR 62

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