Conserved Protein Domain Family
RING-HC_TRIM38_C-IV

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cd16600: RING-HC_TRIM38_C-IV 
RING finger, HC subclass, found in tripartite motif-containing protein 38 (TRIM38) and similar proteins
TRIM38, also known as RING finger protein 15 (RNF15) or zinc finger protein RoRet, is an E3 ubiquitin-protein ligase that promotes K63- and K48-linked ubiquitination of cellular proteins and also catalyzes self-ubiquitination. It negatively regulates Tumor necrosis factor alpha(TNF-alpha)- and interleukin-1beta-triggered Nuclear factor-kappaB (NF-kappaB) activation by mediating lysosomal-dependent degradation of transforming growth factor beta (TGFbeta)-activated kinase 1 (TAK1)-binding protein (TAB)2/3, two critical components of the TAK1 kinase complex. It also inhibits TLR3/4-mediated activation of NF-kappaB and interferon regulatory factor 3 (IRF3) by mediating ubiquitin-proteasomal degradation of TNF receptor-associated factor 6 (Traf6) and NAK-associated protein 1 (Nap1), respectively. Moreover, TRIM38 negatively regulates TLR3-mediated interferon beta (IFN-beta) signaling by targeting ubiquitin-proteasomal degradation of TIR domain-containing adaptor inducing IFN-beta (TRIF). It functions as a valid target for autoantibodies in primary Sjogren"s Syndrome. TRIM38 belongs the C-IV subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, a B-box, and two coiled coil domains, as well as a B30.2/SPRY (SplA and ryanodine receptor) domain positioned C-terminal to the RBCC domain.
Statistics
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PSSM-Id: 319514
View PSSM: cd16600
Aligned: 4 rows
Threshold Bit Score: 92.2505
Threshold Setting Gi: 521023989
Created: 20-Apr-2016
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens TRIM31 (2YSL) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
Feature 1           #  #           # #  #  #                     #  # 
gi 21362879   13 EATCSICLSLMtNPVSINCGHSYCHLCITDFFknpsq--kqlrqETFCCPQCR 63
gi 521023989  13 EATCSICLHLMaEPVSISCGHSYCQACLLRFVgppsslpseqdtETFSCPQCQ 65
gi 589811518  13 EVTCAICLLLMaEPVSISCGHSYCRQCIKDFLknlhq--eepslNVFSCPHCR 63
gi 75060493    9 EATCSICLHLMtNAVSISCGHSYCHVCIVSFFenlnr--mtpglKTFSCPQCR 59

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