Conserved Protein Domain Family
RING-HC_TRIM62_C-IV

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cd16608: RING-HC_TRIM62_C-IV 
RING finger, HC subclass, found in tripartite motif-containing protein 62 (TRIM62) and similar proteins
TRIM62, also known as Ductal Epithelium Associated Ring Chromosome 1 (DEAR1), is a cytoplasmic E3 ubiquitin-protein ligase that was identified as a dominant regulator of acinar morphogenesis in the mammary gland. It is implicated in the inflammatory response of immune cells by regulating the Toll-like receptor 4 (TLR4) signaling pathway, leading to increased activity of the activator protein 1 (AP-1) transcription factor in primary macrophages. It is also involved in muscular protein homeostasis, especially during inflammation-induced atrophy, and may play a role in the pathogenesis of ICU-acquired weakness (ICUAW) by activating and maintaining inflammation in myocytes. Moreover, TRIM62 facilitates K27-linked poly-ubiquitination of CARD9 and also regulates CARD9-mediated anti-fungal immunity and intestinal inflammation. Furthermore, TRIM62 is involved in the regulation of apical-basal polarity and acinar morphogenesis. It also functions as a chromosome 1p35 tumor suppressor and negatively regulates transforming growth factor beta (TGFbeta)-driven epithelial-mesenchymal transition (EMT) through binding to and promoting the ubiquitination of SMAD3, a major effector of TGFbeta-mediated EMT. TRIM62 belongs to the C-IV subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, as well as a B30.2/SPRY (SplA and ryanodine receptor) domain positioned C-terminal to the RBCC domain.
Statistics
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PSSM-Id: 319522
View PSSM: cd16608
Aligned: 5 rows
Threshold Bit Score: 108.225
Threshold Setting Gi: 187608599
Created: 12-Nov-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens TRIM31 (2YSL) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
Feature 1             #  #           # #  #  #               #  #  
gi 74752380    6 KDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQeaqgarDCPECRR 55
gi 123702983   6 KDELLCSICLSIYQDPVSFGCEHYFCRKCITEHWSRQehhgtrDCPECRR 55
gi 187608599   6 KDELLCSICLSIYQDPVSFGCEHYFCRKCITEHWSRQkhggtlDCPECRR 55
gi 632960008   6 KDELLCSICLSMYQDPVSFGCEHYFCRKCITEHWSRQdhc-trDCPECRR 54
gi 971429638   6 KDELLCSICLSIYQDPVSFGCEHYFCRRCITEHWVRQepqgarDCPECRR 55

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