Conserved Protein Domain Family
RING-HC_TRIM65_C-IV

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cd16609: RING-HC_TRIM65_C-IV 
RING finger, HC subclass, found in tripartite motif-containing protein TRIM65 and similar proteins
TRIM65 is an E3 ubiquitin-protein ligase that interacts with the innate immune receptor MDA5 enhancing its ability to stimulate interferon-beta signaling. It functions as a potential oncogenic protein that negatively regulates p53 through ubiquitination, providing insight into development of novel approaches targeting TRIM65 for non-small cell lung carcinoma (NSCLC) treatment, and also overcoming chemotherapy resistance. Moreover, TRIM65 negatively regulates microRNA-driven suppression of mRNA translation by targeting TNRC6 proteins for ubiquitination and degradation. TRIM65 belongs to the C-IV subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, as well as a B30.2/SPRY (SplA and ryanodine receptor) domain positioned C-terminal to the RBCC domain.
Statistics
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PSSM-Id: 319523
View PSSM: cd16609
Aligned: 7 rows
Threshold Bit Score: 78.3008
Threshold Setting Gi: 847174448
Created: 20-Apr-2016
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens TRIM31 (2YSL) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
Feature 1           #  #           # #  #  #                    #  # 
gi 296453004   10 LTCAICLGLYqdPVTLPCGHNFCGACIRDWWDrc---------gkACPECR 51
gi 847174448   12 LTCSICLGLFntPVTIPCGHNFCGECLELAWEackl------geyRCPQCM 56
gi 699650808   13 LQCSICLELFrvPVTLPCGHNFCKCCISDHWHkqeqvpggakkgyKCPECR 63
gi 301621379   15 LKCSICLELFtmPVSTACGHNFCQKCINDHWDqevrk----qipySCPRCR 61
gi 591356728   13 LVCSICLEMFgtAVTMPCGHNFCMKCINNHWDkeekeaspdkkdyTCPDCR 63
gi 465966076  469 IVCPICLEVFtdPVTTACGHNFCMDCLQDYWDhqavi----gecpYCPQCR 515
gi 557026798   14 MTCCVCQELFkdPVTLRCGHNFCRECVREYWKekt--------sqSCPICR 56

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