Conserved Protein Domain Family
RING-HC_TRIM68_C-IV

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cd16610: RING-HC_TRIM68_C-IV 
RING finger, HC subclass, found in tripartite motif-containing protein 68 (TRIM68) and similar proteins
TRIM68, also known as RING finger protein 137 (RNF137) or SSA protein SS-56 (SS-56), is an E3 ubiquitin-protein ligase that negatively regulates Toll-like receptor (TLR)- and RIG-I-like receptor (RLR)-driven type I interferon production by degrading TRK fused gene (TFG), a novel driver of IFN-beta downstream of anti-viral detection systems. It also functions as a cofactor for androgen receptor-mediated transcription through regulating ligand-dependent transcription of androgen receptor in prostate cancer cells. Moreover, TRIM68 is a cellular target of autoantibody responses in Sjogren"s syndrome (SS), as well as systemic lupus erythematosus (SLE). It is also an auto-antigen for T cells in SS and SLE. TRIM68 belongs the C-IV subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, a B-box, and two coiled coil domains, as well as a B30.2/SPRY (SplA and ryanodine receptor) domain positioned C-terminal to the RBCC domain.
Statistics
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PSSM-Id: 319524
View PSSM: cd16610
Aligned: 5 rows
Threshold Bit Score: 105.784
Threshold Setting Gi: 431923030
Created: 20-Apr-2016
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens TRIM31 (2YSL) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
Feature 1           #  #           # #  #  #                 #  # 
gi 74748376   13 EVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGEsqNWGYTCPLCR 61
gi 584085359  13 ELACPICMAYLREPVSIDCGHSFCHSCLAGLWEVPGEsqNWGYTCPLCR 61
gi 344249463  13 EVNCPICMTFLREPVSISCGHTFCHSCLSGLWKLSGEsqDWGYTCPLCR 61
gi 431923030  13 EVACPICMTFLREPVSIDCGHSFCQGCISGLWEVPGEfhNWGYTCPLCR 61
gi 81900965   13 EVNCPICMTFLREPVSISCGHTFCHSCLSGLWKLPGEsqNLSYTCPLCR 61

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