Conserved Protein Domain Family
mRING-HC-C4C4_Asi1p_like

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cd16616: mRING-HC-C4C4_Asi1p_like 
Modified RING finger, HC subclass (C4C4-type), found in Saccharomyces cerevisiae amino acid sensor-independent protein Asi1p, Asi3p and similar proteins
Asi1p and Asi3p are inner nuclear membrane proteins that act as negative regulators of SPS (Ssy1-Ptr3-Ssy5)-sensor signaling in yeast. Together with Asi2p, they assemble into an Asi complex that functions in the SPS amino acid sensing pathway involved in degradation of Stp1 and Stp2 transcription factors. Both Asi1p and Asi3p contain five membrane-spanning domains, as well as highly conserved RING fingers at their extreme C termini, which are a C4C4-type RING finger motif whose overall folding is similar to that of the C3HC4-type RING-HC finger.
Statistics
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PSSM-Id: 319530
View PSSM: cd16616
Aligned: 7 rows
Threshold Bit Score: 87.1238
Threshold Setting Gi: 365986829
Created: 24-Nov-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding sitemodified
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus Hakai (3VK6) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
Feature 1         #  #           # #   #  #              #  #    
gi 1730603    568 CAVCKvneRNTVLWPCRCFAICEDCRISLglrg---fstCVCCRSKV 611
gi 470317237  560 CVICCsgiRNIVLWPCRCLALCDDCRKTLamrn---fkeCPCCRQPV 603
gi 901672244  743 CVICQtnvREIITWPCKCFAICESCRLSLvskg---iegCVCCRREV 786
gi 39979160   985 CVVCQcapRTIIVWPCRCLSLCDECRVSLamnn---fdkCVCCRREV 1028
gi 646311964  803 CVICTvepRQIICWPCRCLAMCDDCRESMasrsaaskhrCPCCRRTV 849
gi 365986829  612 CVLCKrhrRRIVLWPCNCLTICDECRLAIgrrg---ttkCICCAEPV 655
gi 347595637  624 CLICKvnkRNIVTWPCRCLALCDDCRISLgykg---fatCVSCDSEV 667

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