1UR6,1E4U,5AIE


Conserved Protein Domain Family
mRING-HC-C4C4_CNOT4

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cd16618: mRING-HC-C4C4_CNOT4 
Click on image for an interactive view with Cn3D
Modified RING finger, HC subclass (C4C4-type), found in CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
NOT4, also known as CCR4-associated factor 4, E3 ubiquitin-protein ligase CNOT4, or potential transcriptional repressor NOT4, is a component of the multifunctional CCR4-NOT complex, a global regulator of RNA polymerase II transcription. It associates with polysomes and contributes to the negative regulation of protein synthesis. NOT4 functions as an E3 ubiquitin-protein ligase that interacts with a specific E2, Ubc4/5 in yeast, and the ortholog UbcH5B in humans, and ubiquitylates a wide range of substrates, including ribosome-associated factors. Thus, it plays a role in cotranslational quality control (QC) through ribosome-associated ubiquitination and degradation of aberrant peptides. NOT4 contains a C4C4-type RING finger motif, whose overall folding is similar to that of the C3HC4-type RING-HC finger, a central RNA recognition motif (RRM), and a C-terminal domain predicted to be unstructured.
Statistics
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PSSM-Id: 319532
View PSSM: cd16618
Aligned: 47 rows
Threshold Bit Score: 66.0989
Threshold Setting Gi: 551634325
Created: 31-Jul-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding sitepolypeptidemodified
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
Feature 1         #  #              # #    #  #           #  #  
1UR6_B          3 CPLCMEPLEIDDi-nFFPCTCGYQICRFCWHRIRtdeNGLCPACRK 47
gi 15221416   212 CPICSELMDATDl-eFEPCTCGFRICLFCHNKISe-nEARCPACRK 255
gi 60472442     8 CPLCLDELSKADr-kFRPCPCGYQICVFCFERIReseQNRCPACRK 52
gi 148910455  282 CPICYEDLDATDs-nFVPCACGFHLCLFCHKRIVe-qDGRCPSCRN 325
gi 157437504   12 CPLCCNKMTGQDellFFPCTCNYQVCAFCFDKVK---GGQCPHCRT 54
gi 158283666   56 CPLCVEDLDETDm-sFQPCPCGYRMCLFCFEKLKlhcSSVCPNCRR 100
gi 162690033  572 CPICTEELDVTDs-sYIPCTCGFQLCLFCYHRISs-dDGRCPGCRK 615
gi 284095351   12 CPICCEDLDITDk-hFQPCPCGFKICSWCWNKIDn-tSKRCPNCRR 55
gi 313239272   13 CPLCIELLNHDLn--FFPCECAFQICSICWNRIKeleGNLCPNCRT 56
gi 675382492   22 CPKCSEVLDVEEl-nFFPCECHYQLCLFCWNELKs-gDRRCPNCHK 65

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