3LRQ


Conserved Protein Domain Family
mRING-HC-C4C4_TRIM37_C-VIII

?
cd16619: mRING-HC-C4C4_TRIM37_C-VIII 
Click on image for an interactive view with Cn3D
Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
TRIM37, also known as mulibrey nanism protein, or MUL, is a peroxisomal E3 ubiquitin-protein ligase that is involved in the tumorigenesis of several cancer types, including pancreatic ductal adenocarcinoma (PDAC), hepatocellular carcinoma (HCC), breast cancer, and sporadic fibrothecoma. It mono-ubiquitinates histone H2A, a chromatin modification associated with transcriptional repression. Moreover, TRIM37 possesses anti-HIV-1 activity, and interferes with viral DNA synthesis. Mutations in the human TRIM37 gene (also known as MUL) cause Mulibrey (muscle-liver-brain-eye) nanism, a rare growth disorder of prenatal onset characterized by dysmorphic features, pericardial constriction, and hepatomegaly. TRIM37 belongs to the C-VIII subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C4C4-type RING finger, whose overall folding is similar to that of the typical C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, as well as a MATH (meprin and TRAF-C homology) domain positioned C-terminal to the RBCC domain. Its MATH domain has been shown to interact with the TRAF (TNF-Receptor-Associated Factor) domain of six known TRAFs in vitro.
Statistics
?
PSSM-Id: 319533
View PSSM: cd16619
Aligned: 31 rows
Threshold Bit Score: 61.2105
Threshold Setting Gi: 122120586
Created: 3-May-2013
Updated: 18-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
 
Zn binding sitemodified
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:3LRQ; Homo sapiens TRIM37 binds two Zn2+ ions through its C4C4-type RING finger.
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
Feature 1           #  #         #  #    #  #            #  # 
3LRQ_A         23 FRCFICXEKlrDARLCPHCSKLCCFSCIRRWLTEqr-aqCPHCR 65
gi 452824251  107 FRCFICFGRleNPRLCPCCGKMCCLSCIRRWLAQhn--eCPHCR 148
gi 857969780   26 LRCFICFDRvvDAHLCPSCSSMCCKTCIVRWLTErr-pqCPHCQ 68
gi 284085768  130 VKCFLCFNKpsSPHLCPCCSKIVCLGCAKKWISEks--sCPNCR 171
gi 122120586  127 YFCQICHNIlwQPVSCNHCSKIYCRDCLSRWVDQys--tCPTCR 168
gi 122129505   28 IKCSICLNSpkNPRFCPRCSALFCLECIDRWIISnp--tCPACR 69
gi 167516100  981 FQCHICFSQaiDHRSCPSCTSIYCGACLNRWYSStnnpsCPNCR 1024
gi 403376046  271 FKCFICFGKvaNAVMCPHCSKLCCRDCIKKWLNEqr-qsCPHCR 313
gi 923120201   19 FRCFICMARveGAVMCPACSKMGCRACMSTWLVQra--tCPHCR 60
gi 313232074    8 FQCLVCMAGlqDAHLCPKCSKFFCKECIIRWVSRhr--qCPHCR 49

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap