Conserved Protein Domain Family
RING-HC_RFPL4B
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cd16623: RING-HC_RFPL4B 
RING finger, HC subclass, found in Ret finger protein-like 4B (RFPL4B) and similar proteins
RFPL4B, also called RING finger protein 211 (RNF211), is an uncharacterized RING finger protein containing a typical C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438285
Aligned: 4 rows
Threshold Bit Score: 108.748
Created: 29-Jan-2016
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  #  #           # #  #  #              #  #           
Q6ZWI9         1 MAKRLQAELSCPVCLDFFScSISLSCTHVFCFDCIQRYILENHDfrAMCPLCRDVVKVPALEE 63  human
NP_001171254  21 MENILEMEATCAICLDIYShPIYLSCAHILCFDCGKKWMTKKEDliMTCPVCRKEQKRPVKYD 83  house mouse
XP_012505575   1 MATSLQEKAMCPVCLDFFSnPISLSCAHVFCFDCMQTWVSKREDskLTCPLCRESSEKPPLEE 63  Coquerel's sifaka
XP_005337484   1 MDRRLEVEIFCPICLELFFdPISLSCSHIFCFHCIQDWLRIREDsiLICPLCRRENKKPVREE 63  thirteen-lined ground squirrel

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