5EDV


Conserved Protein Domain Family
mRING-HC-C4C4_RBR_HOIP

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cd16631: mRING-HC-C4C4_RBR_HOIP 
Click on image for an interactive view with Cn3D
Modified RING finger, HC subclass (C4C4-type), found in HOIL-1-interacting protein (HOIP) and similar proteins
HOIP, also known as RING finger protein 31 (RNF31) or zinc in-between-RING-finger ubiquitin-associated domain protein, together with HOIL-1 and SHARPIN, forms the E3-ligase complex (also known as linear-ubiquitin-chain assembly complex LUBAC) that regulates NF-kappaB activity and apoptosis. It also interacts with the atypical mammalian orphan receptor DAX-1, trigger DAX-1 ubiquitination and stabilization, and participate in repressing steroidogenic gene expression. HOIP contains three Npl4 zinc fingers, a central ubiquitin-associated (UBA) domain responsible for the interaction with the N-terminal ubiquitin-like domain (UBL) of HOIL-1L, a RBR domain, and a C-terminal linear chain determining domain (LDD). The RBR domain was previously known as RING-BetweenRING-RING domain or TRIAD [two RING fingers and a DRIL (double RING finger linked)] domain. Based on current understanding of the structural biology of RBR ligases, the nomenclature of RBR has been corrected as RING-BRcat (benign-catalytic)-Rcat (required-for-catalysis) recently. The RBR (RING1-BRcat-Rcat) domain use an auto-inhibitory mechanism to modulate ubiquitination activity, as well as a hybrid mechanism that combines aspects from both RING and HECT E3 ligase function to facilitate the ubiquitination reaction. This family corresponds to the RING domain, a C4C4-type RING finger motif whose overall folding is similar to that of the C3HC4-type RING-HC finger. It is required for RBR-mediated ubiquitination.
Statistics
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PSSM-Id: 319545
View PSSM: cd16631
Aligned: 14 rows
Threshold Bit Score: 87.0028
Threshold Setting Gi: 632991900
Created: 2-Apr-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding sitepolypeptidemodified
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:5EDV; Homo sapiens HOIP binds two Zn2+ ions through its C4C4-type RING-HC finger.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
Feature 1          #  #              # #  #  #                  #  #   
5EDV_A          6 ECAVCGwalPHNRMQALTSCECTICPDCFRQHFTIALKEKHItDMVCPACGRP 58
gi 260834815 1255 ECQVCTdvlPQHKLLVLTHCSCEVCVSCMKQYFTITIRDKNIkDMICPVCSQP 1307
gi 938064156  597 ECPICLsvfPHSKMQSLTSCQCSVCCDCFQQHFTIVVRDKHIrDMVCPVCWEP 649
gi 918290811  905 ECKICFnshPQTKIMTLCSCDCKFCIGCFQQYFELKINNEPVvTWTCPICGLP 957
gi 557019480  831 ECAVCFysfPRNRMQSLTSCECTICPDCFKQYFTITVKEKNIkDLVCPQCSKP 883
gi 632991900   32 PCPICFemfPRHKMQSLTSCECLMCSGCFKEHFTLIVKERHIkDLVCPICGKP 84
gi 780025311  931 MCSVCYidlPRNKLMSLINCQCMMCRDCVIEHFEIIAKDKSImKGKCPHCDQP 983
gi 156399497  645 ECIVCMdlkPENRMITMLNCQCRFCSDCVSQYVKQIIQEQNImHLVCPACSEP 697
gi 405967412 1330 ECQCCFt-yFPMSKIRTLNCPCKICFDCMKNYFELNIREKHVrNLCCPICQHP 1381
gi 585667979 1260 SCEVCItpmPMNRLYTLSHCQCKICKECMIGYFSVQIREKNIrQCSCPICSEP 1312

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