Conserved Protein Domain Family
mRING-HC-C3HC3D_PHRF1
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cd16635: mRING-HC-C3HC3D_PHRF1 
Modified RING finger, HC subclass (C3HC3D-type), found in PHD and RING finger domain-containing protein 1 (PHRF1) and similar proteins
PHRF1, also known as KIAA1542, or CTD-binding SR-like protein rA9, is a ubiquitin ligase which induces the ubiquitination of TGIF (TG-interacting factor) at lysine 130. It acts as a tumor suppressor that promotes the transforming growth factor (TGF)-beta cytostatic program through selective release of TGIF-driven promyelocytic leukemia protein (PML) inactivation. PHRF1 contains a plant homeodomain (PHD) finger and a modified C3HC3D-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438297
Aligned: 14 rows
Threshold Bit Score: 101.343
Created: 25-Jul-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C DClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other proteins with a C3HC3D-type RING finger with bound Zn2+ ions
  • Comment:modified RING-HC finger (C3HC3D-type)
  • Comment:consensus of the typical C3HC4-type RING-HC finger: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, X is any amino acid and the number of X residues varies in different fingers.
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #  #              # #  #  #          #  #    
Q9P1Y6        102 DDDAESCPICLNAFrDQAVGTPENCAHYFCLDCIVEWSKNANSCPVDRTLF 152  human
AAI42797       97 DEDSEKCPICLNSFhEQPVATPETCEHYFCLDCILEWSKNANSCPVDRIVF 147  zebrafish
AAI60787       88 DDEGENCPICLNGFrDQVVGTPENCSHYFCLDCIVEWSKNANSCPVDRIAF 138  African clawed frog
EMP34739      112 DDDAENCPICLNTFrNQAVGTPESCAHYFCLDCIVEWSKNANSCPVDRILF 162  green seaturtle
XP_007907543  121 DEDSENCPICLNTFrDQAIGTPESCAHYFCLDCILEWAKNANSCPVDRIIF 171  elephant shark
XP_006814886  166 NDEEEKCPVCLNSFdEQDVGTPESCDHTFCLECILEWSKNVNTCPVDRQIF 216  Saccoglossus kowalevskii
XP_012566798   49 EESDGLCPICLSEFtNQMVGVPKTCNHVFCLECLQEWAKKINNCPVDRTKF 99   Hydra vulgaris
XP_002124973   60 SDGDASCAICLNEFtKQKVGVPNNCRHIFCVDCILEWSKNANSCPVDRIEF 110  Ciona intestinalis
EFX67875       53 TGNSATCPICLLKFkGQAIGFPEVCGHPFCLDCILEWSKTVQTCPNDRRKF 103  common water flea
XP_014343919  104 DEEAENCPICLNIFrDQVVGTPENCAHHFCLDCILEWSKNANSCPIDRILY 154  coelacanth

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