Conserved Protein Domain Family
mRING-HC-C3HC3D_PHRF1

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cd16635: mRING-HC-C3HC3D_PHRF1 
Modified RING finger, HC subclass (C3HC3D-type), found in PHD and RING finger domain-containing protein 1(PHRF1) and similar proteins
PHRF1, also known as KIAA1542, or CTD-binding SR-like protein rA9, is a ubiquitin ligase which induces the ubiquitination of TGIF (TG-interacting factor) at lysine 130. It acts as a tumor suppressor that promotes the transforming growth factor (TGF)-beta cytostatic program through selective release of TGIF-driven promyelocytic leukemia protein (PML) inactivation. PHRF1 contains a plant homeodomain (PHD) finger and a modified C3HC3D-type RING-HC finger.
Statistics
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PSSM-Id: 319549
View PSSM: cd16635
Aligned: 15 rows
Threshold Bit Score: 94.0399
Threshold Setting Gi: 190588707
Created: 25-Jul-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding sitemodified
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens LNX2 (5DIN) binds two Zn2+ ions through its modified RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
Feature 1           #  #              # #  #  #          #  # 
gi 296439275  106 ESCPICLNAFrDQAVGTPENCAHYFCLDCIVEWSKNaNSCPVDR 149
gi 405969328  102 ETCPICLDRLrDQDVGTPESCDHVFCLDCIQEWAKNvNTCPVDR 145
gi 148745146  101 EKCPICLNSFhEQPVATPETCEHYFCLDCILEWSKNaNSCPVDR 144
gi 215494364   65 ERCPICLNRFlGQEEGTPESCDHVFCLDCIQEWARNvNTCPVDR 108
gi 585652239  170 EKCPVCLNSFdEQDVGTPESCDHTFCLECILEWSKNvNTCPVDR 213
gi 919065457  154 ERCPVCLNRLlDQDVGTPEACDHNFCLECINEWAKNvNTCPVDR 197
gi 780161276  177 EKCAICLRSFnDQEVGSPESCDHTFCFECIYEWSKNvTTCPVDR 220
gi 198428271   64 ASCAICLNEFtKQKVGVPNNCRHIFCVDCILEWSKNaNSCPVDR 107
gi 229293849  124 ESCPICLNEFeLQEVGTPVNCQHNFCIDCILEWSKNtNSCPVDR 167
gi 321456775   57 ATCPICLLKFkGQAIGFPEVCGHPFCLDCILEWSKTvQTCPNDR 100

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