Conserved Protein Domain Family
mRING-HC-C3HC3D_SCAF11

?
cd16636: mRING-HC-C3HC3D_SCAF11 
Modified RING finger, HC subclass (C3HC3D-type), found in SR-related and CTD-associated factor 11 (SCAF11) and similar proteins
SCAF11, also known as CTD-associated SR protein 11 (CASP11), renal carcinoma antigen NY-REN-40, SC35-interacting protein 1 (Sip1), Serine/arginine-rich splicing factor 2 (SRSF2)-interacting protein, or splicing regulatory protein 129 (SRrp129), is a novel arginine-serine-rich (RS) domain-containing protein essential for pre-mRNA splicing. It functions as an auxiliary splice factor interacting with the spliceosomal component SC35, promoting RNAPII elongation. In addition to SR proteins, such as SC35, ASF/SF2, SRp75, and SRp20, SCAF11 also associates with U1-70K and U2AF65, proteins associated with 5' and 3' splice sites, respectively. SCAF11 contains an N-terminal modified C3HC3D-type RING-HC finger, an internal serine-arginine rich domain (SR domain), and a C-terminal SRI domain.
Statistics
?
PSSM-Id: 438298
Aligned: 7 rows
Threshold Bit Score: 97.9135
Created: 2-May-2013
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C DClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other proteins with a C3HC3D-type RING finger with bound Zn2+ ions
  • Comment:modified RING-HC finger (C3HC3D-type)
  • Comment:consensus of the typical C3HC4-type RING-HC finger: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, X is any amino acid and the number of X residues varies in different fingers.
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1           #  #              # #  #  #          #  #         
Q99590         39 DRCPICLNCLlEKEVGFPESCNHVFCMTCILKWAETlaSCPIDRKPFQAVFK 90   human
NP_001182499   38 DTCPICLNCLlEQEIGFPENCSHTFCMTCILKWAETqaSCPIDRRPFQAVCQ 89   chicken
AAI55906       38 ERCPICLNFLrKDDVAFPENCYHAFCFTCILKWSETstSCPVDRKPFQAVMK 89   African clawed frog
XP_006011649   45 DRCPICLNCLlEQEVAFPDNCCHVFCLACILKWAETatSCPVDRKHFQAVYK 96   coelacanth
XP_007901061   41 DLCPICLCCLvEQELAVPESCSHIFCLRCILKWAEKlsSCPIDRKPFTAVYK 92   elephant shark
XP_005164518   22 QRCPICLNRPrRSDRAVPDCCRHVYCSACILRWAQMvqSCPVDRRPFSVIFL 73   zebrafish
RXM29927      166 DRCPICLNLLlQQELALPENCCHVFCLSCILKWAETvtSCPIDRKPFQAIYK 217  sterlet

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap