Conserved Protein Domain Family
mRING-HC-C3HC3D_SCAF11

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cd16636: mRING-HC-C3HC3D_SCAF11 
Modified RING finger, HC subclass (C3HC3D-type), found in SR-related and CTD-associated factor 11 (SCAF11) and similar proteins
SCAF11, also known as CTD-associated SR protein 11 (CASP11), renal carcinoma antigen NY-REN-40, SC35-interacting protein 1 (Sip1), Serine/arginine-rich splicing factor 2 (SRSF2)-interacting protein, or splicing regulatory protein 129 (SRrp129), is a novel arginine-serine-rich (RS) domain-containing protein essential for pre-mRNA splicing. It functions as an auxiliary splice factor interacting with spliceosomal component SC35 promoting RNAPII elongation. In addition to SR proteins, such as SC35, ASF/SF2, SRp75, and SRp20, SCAF11 also associates with U1-70K and U2AF65, proteins associated with 5' and 3' splice sites, respectively. SCAF11 contains an N-terminal modified C3HC3D-type RING-HC finger, an internal serine-arginine rich domain (SR domain), and a C-terminal SRI domain.
Statistics
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PSSM-Id: 319550
View PSSM: cd16636
Aligned: 6 rows
Threshold Bit Score: 81.3756
Threshold Setting Gi: 161611655
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding sitemodified
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens LNX2 (5DIN) binds two Zn2+ ions through its modified RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
Feature 1          #  #              # #  #  #          #  # 
gi 251757337   40 RCPICLNCLlEKEVGFPESCNHVFCMTCILKWAETlaSCPIDR 82
gi 307133752   39 TCPICLNCLlEQEIGFPENCSHTFCMTCILKWAETqaSCPIDR 81
gi 161611655   39 RCPICLNFLrKDDVAFPENCYHAFCFTCILKWSETstSCPVDR 81
gi 557022826   46 RCPICLNCLlEQEVAFPDNCCHVFCLACILKWAETatSCPVDR 88
gi 632937786   42 LCPICLCCLvEQELAVPESCSHIFCLRCILKWAEKlsSCPIDR 84
gi 528475678   23 RCPICLNRPrRSDRAVPDCCRHVYCSACILRWAQMvqSCPVDR 65

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